Abstract
URETHANE injected, given by mouth, or applied to the skin, induces the formation of multiple lung adenomata in mice and rats. It also inhibits the growth of some transplanted animal tumours, and induces remissions in human leukæmia. Its many other biological effects include the induction of chromosome abnormalities and mutations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Salaman, M. H., and Roe, F. J. C., Brit. J. Cancer., 7, 472 (1953).
Berenblum, I., and Shubik, P., Brit. J. Cancer., 1, 379 (1947).
Haddow, A., and Sexton, W. A., Nature, 157, 500 (1946).
Boyland, E., Cancer Res., 12, 77 (1952).
Buchanan, J. M., Sonne, J. C., and Delluva, A. M., J. Biol. Chem., 173, 81 (1948).
Totter, J. R., Volkin, E., and Carter, C. E., J. Amer. Chem. Soc., 73, 1521 (1951).
Skipper, H. E., Bennett, L. L., Bryan, C. E., White, L., Newton, M. A., and Simpson, L., Cancer Res., 11, 46 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROE, F. Tumour-initiating Action of Urethane and its Inhibition by Purine Precursors. Nature 175, 636–637 (1955). https://doi.org/10.1038/175636b0
Issue Date:
DOI: https://doi.org/10.1038/175636b0
- Springer Nature Limited
This article is cited by
-
Der chemismus der urethaninduzierten Mutationen 25 Jahre nach ihrer Entdeckung
Molecular and General Genetics MGG (1967)
-
Zur Mutagenit�t von Urethanen
Zeitschrift f�r Vererbungslehre (1962)