Protective Action of Monospecific Anti-Brucella Sera in Mice

Abstract

MONOSPECIFIC anti-Brucella sera have been used in the past for serological identification of Brucella strains, on the basis of their property of agglutinating homologous organisms to a higher titre. It was considered of interest to determine whether these sera had immunological in addition to serological specificity–in other words, whether an absorbed anti-Brucella abortus serum would afford better protection against Br. abortus than against Br. melitensis and vice versa. A passive protection test in mice was employed. This test will be described in detail elsewhere (Sulitzeanu¹) and therefore only a brief description of the methods will be given here.