Abstract
Perkins1 and Whitehouse2 have shown how chromosome centromeres can be mapped by the analysis of unordered tetrads of spores (or gametes), provided segregation is occurring at three unlinked loci. The basis of the method is the determination of the frequency of tetratype tetrads for the loci considered in pairs. If at one of the three loci there is segregation for a lethal or other epistatic factor, the frequency of tetratype tetrads with respect to the other two loci will be indeterminable. Nevertheless, it is still possible to map the genes in relation to their centromeres.
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References
Perkins, D. D., Genetics, 34, 607 (1949).
Whitehouse, H. L. K., Nature, 165, 893 (1950).
Hartshorne, J. N., Ph.D. thesis, Cambridge University (1953).
Papazian, H. P., Genetics, 36, 441 (1951).
Spiegelman, S., Science, 116, 510 (1952).
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WHITEHOUSE, H. Analysis of Unordered Tetrads Segregating for a Lethal or Other Epistatic Factor. Nature 174, 463–464 (1954). https://doi.org/10.1038/174463b0
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DOI: https://doi.org/10.1038/174463b0
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