Abstract
GROUP B Coxsackie viruses have been shown to be capable of producing a severe pancreatitis in weanling and adult mice1. Necrosis of pancreatic acinar tissue occurs within a few days of infection and involves a high proportion of the cells in affected areas. These observations, together with the affinity of necrotic tissue for acid intravital dyes, have been utilized in the development of a technique for the rapid titration of pancreatotropic group B strains in weaned mice. Briefly, the technique is as follows.
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HOWES, D. Intravital Staining in Titrations of Group B Coxsackie Viruses in Weaned Mice. Nature 173, 270–271 (1954). https://doi.org/10.1038/173270a0
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DOI: https://doi.org/10.1038/173270a0
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