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Structure of Adenylic Acids a and b

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Abstract

WITH the demonstration1 that the main internucleotidic linkage in ribonucleic acids is b : 5′, it is clear that a final decision between 2′ : 5′ and 3′ : 5′ as possible linkage positions2 can be reached by determining the location of the phosphoryl group in the isomeric a and b nucleotides obtained by alkaline hydrolysis of ribonucleic acids3. Brown and Todd4 showed that these nucleotides are the 2′- and 3′-phosphates of the corresponding nucleosides, although not necessarily respectively.

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References

  1. Brown, D. M., and Todd, A. R., J. Chem. Soc., 2040 (1953). Brown, D. M., Heppel, L. A., and Hilmoe, R. J., J. Chem. Soc. (in the press). Whitfield, P. R., and Markham, R., Nature, 171, 1151 (1953).

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  2. Brown, D. M., and Todd, A. R., J. Chem. Soc., 52 (1952).

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  9. Corby, N. S., Kenner, G. W., and Todd, A. R., J. Chem. Soc., 3669 (1952).

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Authors and Affiliations

  1. University Chemical Laboratory, Cambridge

    D. M. BROWN, G. D. FASMAN, D. I. MAGRATH & A. R. TODD

  2. Cavendish Laboratory, Cambridge

    W. COCHRAN & M. M. WOOLFSON

Authors
  1. D. M. BROWN
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  2. G. D. FASMAN
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  3. D. I. MAGRATH
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  4. A. R. TODD
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  5. W. COCHRAN
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  6. M. M. WOOLFSON
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BROWN, D., FASMAN, G., MAGRATH, D. et al. Structure of Adenylic Acids a and b . Nature 172, 1184–1185 (1953). https://doi.org/10.1038/1721184a0

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