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Studies with Erythrocytes labelled with Radioactive p-Iodophenylhydroxylamine

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Abstract

A TECHNIQUE has been developed in this laboratory for the rapid labelling of erythrocytes in vivo and in vitro using p-iodophenylhydroxylamine (I.C6H4.NH.OH) containing radioactive iodine. This compound, together with its green oxidation product p-iodonitrosobenzene (I.C6H4.NO), has a remarkable affinity for hæmoglobin, and in spite of its insolubility in water rapidly penetrates red cells and combines firmly and stoichiometrically with the cell pigment1. The reaction with hæmoglobin and some of its derivatives has been examined in detail and appears to be irreversible so long as the hæm molecule remains intact.

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References

  1. Crick, J., and Jackson, H., Brit. J. Pharmacol. Chemother., 7, 142 (1952); and also in the press.

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Authors and Affiliations

  1. Department of Experimental Radiation Therapeutics, Christie Hospital and Holt Radium Institute, Manchester

    HAROLD JACKSON

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  1. HAROLD JACKSON
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JACKSON, H. Studies with Erythrocytes labelled with Radioactive p-Iodophenylhydroxylamine. Nature 172, 80–81 (1953). https://doi.org/10.1038/172080a0

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