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Acquired Resistance to ‘Melarsen’, Tryparsamide and Amidines in Pathogenic Trypanosomes after Treatment with ‘Melarsen’ Alone

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Abstract

‘MELARSEN’ (disodium - p - melaminylphenylarsonate1, I) is active against tryparsamide-resistant trypanosome strains both in the field2 and in the laboratory3, and is more effective than tryparsamide (sodium p-glycineamidophenylarsonate) in rendering trypanocidal the cerebrospinal fluid in rabbits4. In view of these properties, the behaviour of a ‘Melarsen’-resistant trypanosome strain seemed to merit investigation.

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Authors and Affiliations

  1. Wellcome Laboratories of Tropical Medicine, Euston Road, London, N.W.1

    I. M. ROLLO

  2. Department of Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London, W.C.1

    J. WILLIAMSON

Authors
  1. I. M. ROLLO
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  2. J. WILLIAMSON
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ROLLO, I., WILLIAMSON, J. Acquired Resistance to ‘Melarsen’, Tryparsamide and Amidines in Pathogenic Trypanosomes after Treatment with ‘Melarsen’ Alone. Nature 167, 147–148 (1951). https://doi.org/10.1038/167147a0

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