Abstract
INVESTIGATIONS by A. R. Todd1, H. Rinderknecht2, W. B. Geiger3 and others have shown that many unsaturated ketones with the grouping —C = C—CO—, also present in a number of naturally occurring antibiotics, possess antibacterial action. In our studies on unsaturated ketones, we found that chalkone, flavanone, flavone and some of their derivatives, for example, buteine (2,4,3',4'-tetrahydroxychalkone). a substance of vegetable origin, showed a marked inhibition of the growth of Staph. aureus. Also extracts of plants containing flavanones, flavones or flavonoles were found to be bacteriostatic4. Furthermore, we have prepared a number of synthetic chalkones of which some compounds suppressed the growth at high dilutions.
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References
Marrian, D. H., Russell, P. B., and Todd, A. R., J. Chem. Soc., 1419 (1947).
Rinderknecht, H., Ward, J. L., Bergel, F., and Morrison, A. L., Biochem. J., 41, 463 (1947).
Geiger, W. B., Arch. Biochem., 16, 423 (1948).
Schraufstätter, E., Experientia, 4, 484 (1948).
Schraufstätter, E., and Deutsch, S., Z. Naturforsch., 3 b, 163 (1948).
Schraufstätter, E., Richter, R., and Ditseheid, W., Arch. f. Dermatol. u. Syph., 188, 259 (1949).
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SCHRAUFSTÄTTER, E., BERNT, H. Antibacterial Action of Curcumin and Related Compounds. Nature 164, 456–457 (1949). https://doi.org/10.1038/164456a0
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DOI: https://doi.org/10.1038/164456a0
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