Abstract
PREVIOUS work by Mellanby1 and Moran2 has shown that treatment of many proteins with 'Agene' (nitrogen trichloride) produces material which when fed to dogs causes hysteria and epileptiform fits. Radomski, Woodward and Lehman3 found that rabbits are also sensitive to nitrogen trichloride-treated proteins, and we have found it convenient to employ these animals in preference to dogs since they obviously have considerable advantages in the routine semi-quantitative toxicity assays involved in the course of purification experiments.
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References
Mellanby, E., Brit. Med. J., 288 (Aug. 23, 1947).
Moran, T., Lancet, 289 (Aug. 23, 1947).
Radomski, J. L., Woodward, G., and Lehman, A. J., J. Nutrition, 36, 15 (1948).
Tiselius, A., Drake, B., and Hagdahl, L., Experientia, 3, 21 (1947).
Albanese, A. A., J. Biol. Chem., 134, 467 (1940).
Partridge, S. M., Chem. and Indust., 27 (1949).
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BENTLEY, H., MCDERMOTT, E., PACE, J. et al. Action of Nitrogen Trichloride on Proteins: Progress in the Isolation of the Toxic Factor. Nature 163, 675–676 (1949). https://doi.org/10.1038/163675a0
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DOI: https://doi.org/10.1038/163675a0
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