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Further Observations on the 'Incomplete' or 'Blocking' Rh Antibody

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Abstract

WE would like to record a few more observations on the 'incomplete' or 'blocking' Rh antibody recently found in human serum1,2. 'Incomplete' antibody differed from other Rh antibodies in that it failed to agglutinate red cells carrying the equivalent antigen. It did, however, block this antigen, so that subsequent exposure to the homologous 'complete' or agglutinating antibody failed to result in the agglutination of the treated cells. The antigen involved is that called D in Fisher's notation1; other Rh antigens and the antigens A,B, M,N and P are not blocked by this antibody.

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References

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Authors and Affiliations

  1. Department of Pathology, University of Cambridge, and Medical Research Council, Emergency Blood Transfusion Service,

    R. R. A. COOMBS & R. R. RACE

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  1. R. R. A. COOMBS
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  2. R. R. RACE
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COOMBS, R., RACE, R. Further Observations on the 'Incomplete' or 'Blocking' Rh Antibody. Nature 156, 233–234 (1945). https://doi.org/10.1038/156233a0

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