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Pyridine-3-sulphon-(2-pyridyl)-amide; a Note on the Modelling of Chemotherapeutic Agents

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Abstract

THIS compound (I) was prepared for the following reason: pyridine-3-sulphonic acid and its amide were found to inhibit bacterial growth, apparently by interference with nicotinic acid metabolism1. Sulphanilamide appears to act as a therapeutic agent by interfering with the utilization of p-aminobenzoic acid by the invading organisms2, but the 2-aminopyridine derivative(M. & B. 693) is in many cases more effective. Following a rule of thumb method common in chemotherapeutic research, the M. & B. 693 analogue of pyridine-3-sulphonic acid, (I), was prepared and its inhibitory powers compared with those of the parent acid and amide by in vitro tests analogous to those previously described1,2. The compound was found less active than the simple acid and amide.

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References

  1. McIlwain, H., Brit. J. Exp. Path., 21, 136 (1940).

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Authors and Affiliations

  1. (Leverhulme Research Fellow), Department of Bacterial Chemistry (Medical Research Council), Bland Button Institute of Pathology, Middlesex Hospital, London, W.1

    HENRY MCILWAIN

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  1. HENRY MCILWAIN
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MCILWAIN, H. Pyridine-3-sulphon-(2-pyridyl)-amide; a Note on the Modelling of Chemotherapeutic Agents. Nature 146, 653–654 (1940). https://doi.org/10.1038/146653a0

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