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Nature of the Cyclol Bond

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Abstract

THE confirmation by X-ray data1,2 of C2, the A 288-residue cage structure proposed for the insulin molecule3, makes it of interest to consider the nature of the cyclol bond, upon the postulation of which this structure and the cyclol theory of protein structure in general4 depend.The making and breaking of a cyclol bond between an NH group of a polypeptide chain and a CO group of the same or of another polypeptide chain, requires only the migration of an H atom thus:

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Authors
  1. Irving Langmuir
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  2. Dorothy Wrinch
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Langmuir, I., Wrinch, D. Nature of the Cyclol Bond. Nature 143, 49–52 (1939). https://doi.org/10.1038/143049a0

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