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Methæmalbumin (Pseudo-methæmoglobin)

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Abstract

IN a previous communication1, I suggested the name pseudo-methæmoglobin for a new blood pigment, formerly confused with methæmoglobin, which Fairley and Bromfield2 had found in the plasma of blackwater fever cases. Serial quantitative observations based on the degree of dilution necessary for the extinction of the α bands of pseudo-methæmoglobin and oxyhæmoglobin indicated that pseudo-methæmoglobin was derived from extracorpuscular oxyhæmoglobin. Since then we have demonstrated the same pigment in nocturnal hæmoglobinuria, incompatible transfusion3 and pancreatic cyst fluid4. Foy and Kondi5 made a spectrographic analysis of this pigment, and confirmed its incidence in black-water fever in Macedonia.

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References

  1. Fairley, N. H., NATURE, 130, 588 (1937).

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  2. Fairley, N. H., and Bromfield, R. J., Trans. Roy. Soc. Trop. Med. and Hyg., 28, 307 (1934).

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  3. Fairley, N. H., and Bromfield, R. J., Trans. Roy. Soc. Trop. Med. and Hyg., 31, 139 (1937).

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  4. Fairley, N. H., and Bromfield, R. J., Trans. Roy. Soc. Trop. Med. and Hyg., 31, 372 (1938).

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  5. Foy, H., and Kondi, A., Trans. Roy. Soc. Trop. Med. and Hyg., 32, 49 (1938).

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  6. Hoppe-Seyler, F., "Handbuch der physiologisch- und pathologisch-chemischen Analyse", 2 Auflage, 205 (1865).

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Authors and Affiliations

  1. Hospital for Tropical Diseases, London, W.C.1

    N. HAMILTON FAIRLEY

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  1. N. HAMILTON FAIRLEY
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FAIRLEY, N. Methæmalbumin (Pseudo-methæmoglobin). Nature 142, 1156–1157 (1938). https://doi.org/10.1038/1421156a0

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