Kallikrein as a Reynals Factor

Abstract

THE spreading or diffusing factors, also termed Reynals factors or shortly R. factors, after F. Duran-Reynals¹, who found these factors in watery extracts of testicle of mammals, are endowed with the property of enhancing tissue permeability. When indicators, such as Indian ink, trypan blue or diphtheria toxin are added to such extracts and a certain amount of the mixture is injected intra-cutaneously in rabbits, an extensive spread of the particles of Indian ink, trypan blue or the toxin takes place, resulting in much larger coloured or inflamed areas than can be obtained by mixing other substances (excluding the few other R. factors) with the indicators. As a control in experiments with R. factors a mixture of 0·9 per cent sodium chloride with the indicator is generally used.