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Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals

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Figure 1: WASP is recruited through its GTPase-binding domain (GBD) to EPEC pedestals.
Figure 2: Pedestal formation and localization of Arp2/3c to pedestals require the WASP acidic domain.

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Acknowledgements

The authors thank A. Mallavarapu and J. Taunton for helpful discussions, S. Keshavarzi for assistance, M. Welch for Arp2/3c antibodies, H.Miki for N-WASP cDNA, and H. Bourne, A. Johnson and J. Engel for commenting on the manuscript. The work was supported by the H.H.M.I. (O.D.W and B.B.F.), the N.S.E.R.C., Canada (D.L.G), and grants from the M.R.C., Canada (B.B.F), from the N.I.H. (J.W.S. and A.A.), and from the N.C.I. (J.M.B.).

Correspondence and requests for materials should be addressed to D.K.

Supplementary information is available on Nature Cell Biology’s World-Wide Web site (http://www.nature.com/ncb/index.html) or as paper copy from the London editorial office of Nature Cell Biology.

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Author notes

  1. Daniel Kalman, Orion D. Weiner and Arie Abo: These authors contributed equally to this work

Authors and Affiliations

  1. Department of Microbiology and Immunology, G.W. Hooper Foundation Laboratories, University of California at San Francisco, San Francisco, 94143, California, USA

    Daniel Kalman & J. Michael Bishop

  2. Department of Biochemistry, University of California at San Francisco, San Francisco, 94143, California, USA

    Orion D. Weiner & John W. Sedat

  3. and the Department of Microbiology and Immunology, Biotechnology Laboratory, University of British Columbia, Vancouver, BC V6T 1Z3, Canada

    Danika L. Goosney & B. Brett Finlay

  4. Onyx Pharmaceuticals, Richmond, 94806, California, USA

    Arie Abo

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  1. Daniel Kalman
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  2. Orion D. Weiner
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  4. John W. Sedat
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Correspondence to Daniel Kalman.

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Kalman, D., Weiner, O., Goosney, D. et al. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nat Cell Biol 1, 389–391 (1999). https://doi.org/10.1038/14087

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