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Ascorbic Acid as a Precursor of Serum Complement

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Abstract

PARTICULARLY in septicæmia conditions affecting man, the importance of ” alexine” (Bordet) or ” complement” (Ehrlich) in immune processes, although (so far) inexactly defined in scope, is becoming very generally recognised1, 2. Frequent attempts to analyse and define this substance, generally by chemical means, have resulted in the recognition of at least four components or ” end” and ” middle-pieces”3, 4.

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References

  1. Cadham, F., ” Septicaemia: a Method of Treatment”, Amer. J. Med. Sci., 188, 542 (1934).

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  2. Whitby, L. E. H., and Britton, C. J. C., ” Disorders of the Blood”, 45 (J. and A. Churchill, London, 1935).

  3. Gordon, J., and Wormall, A., ” The Action of Ultra-Violet Rays on Complement”, Biochem. J., 22 (4), 909 (1928).

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  4. Gordon, J., and Thompson, F. C., ” The Relationship between the Complement and Opsonin of Normal Serum”, Brit. J. Exp. Path., 16 (1), 101 (1935).

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MARSH, F. Ascorbic Acid as a Precursor of Serum Complement. Nature 137, 618–619 (1936). https://doi.org/10.1038/137618b0

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