Carcinogenic Activity and Substantivity

Abstract

THE significant work of J. W. Cook and his collaborators¹ on the relation between the structure and carcinogenic activity of the higher aromatic hydrocarbons prompts the observation that a similar type of relation holds between the structure of an anthraquinone derivative and the affinity of its leuco-form for textile fibres. With few exceptions, Cook et al. have found that, of the hydrocarbons related to anthracene, those derived by attachment of alkyl groups or hydrocarbon rings to the 1: 2- or 1: 2: 5: 6-positions possessed carcinogenic activity, whilst other orientations were inert.