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Noninvasive visualization of tumors in rodent dorsal skin window chambers

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Abstract

A novel model for evaluating anti-cancer therapies.

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Figure 1: Examples of window chamber tumors.
Figure 2: Simultaneous visualization of a 4T1-GFP-derived window chamber tumor and its associated vasculature.
Figure 3: Sequential documentation of adenovirus-mediated EGFP gene expression in a rat window chamber tumor model.

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Acknowledgements

This study was supported by a generous start-up grant provided by the department of radiation oncology, Duke University Medical Center, and a grant from the Duke University SPORE in breast cancer (C-Y.L.); and grants CA40355, CA42745 from the US National Cancer Institute (M.W.D.). Q.H. is a Raychem/Duane/Roger/John Morris Fellow at the Duke Comprehensive Cancer Center.

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Authors and Affiliations

  1. the department of radiation oncology, Duke University Medical Center, Durham, 27710, NC

    Qian Huang, Siqing Shan, Rod D. Braun, Jennifer Lanzen, Gopal Anyrhambatla, Garheng Kong, Mark W. Dewhirst & Chuan-Yuan Li

  2. the department of radiation oncology, William Beaumont Hospital, Royal Oaks, 48037, MI

    Michael Borelli & Peter Corry

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  1. Qian Huang
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  2. Siqing Shan
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Correspondence to Chuan-Yuan Li.

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Huang, Q., Shan, S., Braun, R. et al. Noninvasive visualization of tumors in rodent dorsal skin window chambers. Nat Biotechnol 17, 1033–1035 (1999). https://doi.org/10.1038/13736

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