Skip to main content

Advertisement

Log in

Estrogen hits the surface

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Abstract

Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Mechanisms of rapid non-genomic receptor-dependent actions of estrogen in four cell types.

References

  1. Razandi, M., Pedram, A., Greene, G.L. & Levin, E.R. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ER alpha and ER beta expressed in Chinese hamster ovary cells. Mol. Endocrinol. 13, 307–319 (1999).

    CAS  PubMed  Google Scholar 

  2. Chen, Z. et al. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J. Clin. Invest. 103, 401–406 (1999).

    Article  CAS  Google Scholar 

  3. Goetz, R.M. et al. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. USA 96, 2788–2793 (1999).

    Article  CAS  Google Scholar 

  4. Garcia-Cardena, G., Fan R., Shah V., et al. Dynamic activation of endothelial nitric oxide synthase Hsp90. Nature 392, 821–824 (1998).

    Article  CAS  Google Scholar 

  5. Williams, J.K., Adams, M.R., Herrington, D.M. & Clarkson, T.B. Short-term administration of estrogen and vascular responses of atherosclerotic coronary arteries. J. Am. Coll. Cardiol. 20, 452–457 (1992).

    Article  CAS  Google Scholar 

  6. Collins, P. et al. 17 beta-Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease. Circulation 92, 24–30 (1995).

    Article  CAS  Google Scholar 

  7. Singer, C.A., Figueroa-Masot, X.A., Batchelor, R.H. & Dorsa, D.M. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J. Neurosci. 19 2455–2463 (1999).

    Article  CAS  Google Scholar 

  8. Kawas, C. et al. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore longitudinal study of aging. Neurology 48, 1517–1521 (1997).

    Article  CAS  Google Scholar 

  9. Migliaccio, A., Di DM, Castoria G., et al. Tyrosine kinase/p21ras/MAP kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15, 1292–1300 (1996).

    Article  CAS  Google Scholar 

  10. Improta-Brears, T. et al. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc. Natl. Acad. Sci. USA 96, 4686–4691 (1999).

    Article  CAS  Google Scholar 

  11. Endoh, H. et al. Rapid activation of MAP kinase by estrogen in the bone cell line. Biochem. Biophys. Res. Commun. 235, 99–102 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Collins, P., Webb, C. Estrogen hits the surface. Nat Med 5, 1130–1131 (1999). https://doi.org/10.1038/13453

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/13453

  • Springer Nature America, Inc.

This article is cited by

Navigation