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Meiosis: Rec8 is the reason for cohesion

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Abstract

During meiosis, sister chromatids produced by chromosome duplication are held together by Rec8, a meiosis-specific cohesion protein. Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion.

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Figure 1: Regulation of sister-chromatid cohesion in mitosis.
Figure 2: Regulation of sister-chromatid cohension in meiosis.

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Authors and Affiliations

  1. Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17-233, Cambridge, 02139, Massachusetts, USA

    Chatanika Stoop-Myer & Angelika Amon

Authors
  1. Chatanika Stoop-Myer
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  2. Angelika Amon
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Correspondence to Angelika Amon.

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Stoop-Myer, C., Amon, A. Meiosis: Rec8 is the reason for cohesion. Nat Cell Biol 1, E125–E127 (1999). https://doi.org/10.1038/12956

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