Skip to main content
SpringerLink
Log in

Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish

  • Correspondence
  • Published:

From Nature Genetics

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Distal negative regulatory elements confer tissue-specific expression of zebrafish rag1.
Figure 2: Zebrafish rag1 is expressed in olfactory tissues.

References

  1. Tonegawa, S. Nature 302, 575–581 ( 1983).

    Article  CAS  Google Scholar 

  2. Oettinger, M.A., Schatz, D.G., Gorka, C. & Baltimore, D. Science 248, 1517–1523 (1990).

    Article  CAS  Google Scholar 

  3. Mombaerts, P. et al. Cell 68, 869–877 (1992).

    Article  CAS  Google Scholar 

  4. Shinkai, Y. et al. Cell 68, 855–867 (1992).

    Article  CAS  Google Scholar 

  5. Brown, S.T. et al. J. Immunol. 158, 5071– 5074 (1997).

    CAS  PubMed  Google Scholar 

  6. Fuller, K. & Storb, U. Mol. Immunol. 34, 939–954 (1997).

    Article  CAS  Google Scholar 

  7. Kurioka, H. et al. Mol. Immunol. 33, 1059– 1066 (1996).

    Article  CAS  Google Scholar 

  8. Zarrin, A.A., Fong, I., Malkin, L., Marsden, P.A. & Berinstein, N.L. J. Immunol. 159, 4382– 4394 (1997).

    CAS  PubMed  Google Scholar 

  9. Willett, C.E., Zapata, A.G., Hopkins, N. & Steiner, L.A. Dev. Biol. 182, 331–341 (1997).

    Article  CAS  Google Scholar 

  10. Willett, C.E., Cherry, J.J. & Steiner, L.A. Immunogenetics 45, 394– 404 (1997).

    Article  CAS  Google Scholar 

  11. Jessen, J.R. et al. Proc. Natl Acad. Sci. USA 95, 5121– 5126 (1998).

    Article  CAS  Google Scholar 

  12. Barth, A.L., Justice, N.J. & Ngai, J. Neuron 16, 23– 34 (1996).

    Article  CAS  Google Scholar 

  13. Chess, A. Adv. Immunol. 69, 437–447 (1998).

    Article  CAS  Google Scholar 

  14. Haffter, P. et al. Development 123, 1– 36 (1996).

    CAS  PubMed  Google Scholar 

  15. Driever, W. et al. Development 123, 37– 46 (1996).

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank members of our laboratories for discussions and assistance, and L. Steiner for helpful discussions and support. This work was supported by grants from NIH to S.L. (R01 RR13227-01) and L. Steiner (2RO1 AI08054). C.E.W. supported by NIH grant 9T32 AI07463.

Author information

Authors and Affiliations

  1. Institute of Molecular Medicine and Genetics and Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, 30912, Georgia, USA

    Jason R. Jessen & Shuo Lin

  2. Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA

    Catherine E. Willett

Authors
  1. Jason R. Jessen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Catherine E. Willett
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shuo Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shuo Lin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jessen, J., Willett, C. & Lin, S. Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish. Nat Genet 23, 15–16 (1999). https://doi.org/10.1038/12609

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/12609

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation