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A sonic boom for gene delivery

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Abstract

A new method for infecting embryos with retroviral vectors allows transgenes to be expressed with high efficiency during very early stages of neural development.

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Figure 1: Cross-section of spinal cord from an E12.5 mouse embryo that was infected at E8.5 with retroviral vector expressing an alkaline phosphatase reporter gene.
Figure 2: Sagittal ultrasound image of an E9.5 mouse embryo about to be injected with a high-titer retroviral stock.

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Authors and Affiliations

  1. the Institute of Psychiatry, 1 Windsor Walk, Denmark Hill, SE5 8AF, London, UK

    Jack Price

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  1. Jack Price
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Price, J. A sonic boom for gene delivery. Nat Neurosci 2, 779–780 (1999). https://doi.org/10.1038/12143

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  • DOI: https://doi.org/10.1038/12143

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