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Cholesterol: stuck in traffic

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Abstract

Niemann–Pick type C is a genetic disorder thought to be partly characterized by a defect in cholesterol storage in lysosomes. New findings show that in fact cholesterol accumulates in late endosomes, and this accumulation leads to the redistribution of membrane proteins.

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Figure 1: Trafficking pathways in a nonpolarized cell such as a fibroblast.

References

  1. Kobayashi, T. et al. Nature Cell Biol. 1, 113– 118 (1999).

    Article  CAS  Google Scholar 

  2. Neufeld, E. B. et al. J. Biol. Chem. 274, 9627– 9635 (1999).

    Article  CAS  Google Scholar 

  3. Mukherjee, S., Ghosh, R. N. & Maxfield, F. R. Physiol. Rev. 77, 759– 803 (1997).

    Article  CAS  Google Scholar 

  4. Simons, K. & Ikonen, E. Nature 387, 569–572 (1997).

    Article  Google Scholar 

  5. Mukherjee, S., Soe, T. T. & Maxfield, F. R. J. Cell Biol. 144, 1271– 1284 (1999).

    Article  Google Scholar 

  6. Kobayashi, T. et al. Nature 392, 193–197 (1998).

    Article  Google Scholar 

  7. Liscum, L. & Klansek, J. J. Curr. Opin. Lipidol. 9, 131–135 (1998).

    Article  CAS  Google Scholar 

  8. Mayor, S., Sabharanjak, S. & Maxfield, F. R. EMBO J. 17, 4626– 4638 (1998).

    Article  CAS  Google Scholar 

  9. Rodal, S. K. et al. Mol. Biol. Cell 10, 961– 974 (1999).

    Article  CAS  Google Scholar 

  10. Subtil, A. et al. Proc. Natl. Acad. Sci. USA (in the press).

  11. Tabas, I. Curr. Opin. Lipidol. 6, 260–268 (1995).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, 10021 , New York, USA

    Sushmita Mukherjee & Frederick R. Maxfield

Authors
  1. Sushmita Mukherjee
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  2. Frederick R. Maxfield
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Correspondence to Frederick R. Maxfield.

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Mukherjee, S., Maxfield, F. Cholesterol: stuck in traffic. Nat Cell Biol 1, E37–E38 (1999). https://doi.org/10.1038/10030

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