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Secondary metabolism in simulated microgravity: β-lactam production by Streptomyces clavuligerus

  • A Fang
  • D L Pierson
  • S K Mishra
  • D W Koenig
  • A L Demain

Rotating bioreactors designed at NASA’s Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism. The system examined was β-lactam antibiotic production by Streptomyces clavuligerus. Both growth and β-lactam production occurred in simulated microgravity. Stimulatory effects of phosphate and L-lysine, previously detected in normal gravity, also occurred in simulated microgravity. The degree of β-lactam antibiotic production was markedly inhibited by simulated microgravity.

Keywords: simulated microgravity; gravity; β-lactam antibiotics; Streptomyces clavuligerus; space microbiology 

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Copyright information

© Society for Industrial Microbiology 1997

Authors and Affiliations

  • A Fang
    • 1
  • D L Pierson
    • 2
  • S K Mishra
    • 3
  • D W Koenig
    • 3
  • A L Demain
    • 1
  1. 1.Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USAUS
  2. 2.NASA/Johnson Space Center, USAUS
  3. 3.KRUG Life Sciences, Inc, Houston TX 77058, USAUS

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