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Nature New Biology

, Volume 245, Issue 147, pp 232–234 | Cite as

Evolution of 5S RNA and the Non-randomness of Base Replacement

  • DAVID SANKOFF
  • CRISTIANE MOREL
  • ROBERT J. CEDERGREN
Article

Abstract

SEQUENCES of 5S rRNA have been published for five widely divergent organisms: Escherichia coli, Pseudomonas fluorescens, yeast, human KB carcinoma and Xenopus laevis1–5. The question arises whether sequences for the ancestors of these organisms, represented by X, Y and Z in Fig. 1, can be reconstructed to any degree of confidence; were this possible, statistical analysis of mutation types would become feasible. Such reconstructions are well known in protein studies6 and for tRNAs7, but they are somewhat more difficult for 5S rRNA.

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Copyright information

© Nature Publishing Group 1973

Authors and Affiliations

  • DAVID SANKOFF
    • 1
  • CRISTIANE MOREL
    • 1
  • ROBERT J. CEDERGREN
    • 1
  1. 1.Centre de Recherches Mathématiques and Département de BiochimieUniversité de MontréalMontréal

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