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Biotransformation of solidagenone by Alternaria alternata, Aspergillus niger and Curvularia lunata cultures

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Abstract

The microbiological oxidation of the diterpene solidagenone by Curvularia lunata afforded 3α-hydroxysolidagenone and 3-oxosolidagenone as well as the fungal compounds radicinol and isoradicinol. Fermentation of solidagenone with Aspergillus niger afforded 3β-hydroxy- and 19-hydroxysolidagenone while with Alternaria alternata yielded 3-oxosolidagenone. The structure of 3-oxosolidagenone is presented for the first time.

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Authors and Affiliations

  1. Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile

    G. Schmeda-Hirschmann & L. Astudillo

  2. Centro de Productos Naturales Orgánicos ‘Antonio Gonzalez’, Astrofísico F. Sanchez, 2-38206, La Laguna, Tenerife, Islas Canarias, España

    J.A. Palenzuela

Authors
  1. G. Schmeda-Hirschmann
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  2. L. Astudillo
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  3. J.A. Palenzuela
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Correspondence to G. Schmeda-Hirschmann.

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Schmeda-Hirschmann, G., Astudillo, L. & Palenzuela, J. Biotransformation of solidagenone by Alternaria alternata, Aspergillus niger and Curvularia lunata cultures. World Journal of Microbiology and Biotechnology 20, 93–97 (2004). https://doi.org/10.1023/B:WIBI.0000013317.60257.33

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  • DOI: https://doi.org/10.1023/B:WIBI.0000013317.60257.33

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