Abstract
Measuring intercompartmental, blood and urinarybiochemical parameters during acute bed rest(ABR) and rigorous bed rest (RBR) the aim ofthis work was to disclose if ABR or RBR couldinfluence significantly more and significantlyfaster the body hydration level in normal subjects.Studies conducted during pre-bed rest (BR)period of 3-days and during 7-days period of ABRand RBR. Thirty normal male individuals24.6 ± 5.7 years of age were chosen assubjects. They were divided into three groups:unrestricted active control subjects (UACS),acute bed rested subjects (ABRS) and rigorousbed rested subjects (RBRS). Acute bed restedsubjects confined abruptly to RBR, while theydid not have any prior knowledge of the exactdate and time when they would be subjected toRBR. RBRS were submitted to RBR in apredetermined date and time known to them rightfrom the start of the study. UACS were notsubjected to any form of BR.Fluid loss, urinary and plasma sodium (Na+) andpotassium (K+), plasma osmolality, whole bloodhematocrit (Hct) and hemoglobin (Hb), and totalplasma protein level increased significantly(p < 0.05), while urinary osmolality,extracellular volume (ECV), plasma volume (PV),red cell volume (RCV), blood volume (BV),interstitial volume (IV) and fluid consumptiondecreased significantly (p < 0.05) in ABRS andRBRS compared with their pre-BR values andtheir control (UACS). However, the measuredvariables changed significantly (p < 0.05) moreand significantly faster in ABRS than RBRS.Conversely, whole blood Hct and Hb levels,fluid consumption and fluid loss, urinary andplasma osmolality, urinary and plasmaelectrolytes, plasma protein, ECV, PV, RCV, BVand IV levels were not change in UACS comparedwith their pre-BR values.Significantly greater and significantly fasterintercompartmental, blood and urinarybiochemical changes were observed in ABRS thanRBRS. Body hydration was affected significantlymore and significantly faster in ABR than RBR. It wasconcluded, the more abruptly normal activity isrestricted the smaller the body hydration inbed rested subject is, and probably in patientswho are abruptly confined to RBR.
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Zorbas, Y.G., Yarullin, V.L., Denogratov, S.D. et al. Fluid volume measurements in normal subjects to disclose body hydration during acute bed rest. Int Urol Nephrol 35, 457–465 (2003). https://doi.org/10.1023/B:UROL.0000025636.41034.83
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DOI: https://doi.org/10.1023/B:UROL.0000025636.41034.83