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Diagnostic significance of semiquantitative and quantitative parameters of Tc99m-Ethylenedicystine renal allograft scintigraphy

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Abstract

Objectives: No objective parameters for renalallograft evaluation have yet been describedfor Tc99m-Ethylenedicystine. This studyevaluates the diagnostic significance ofdifferent quantitative and semi-quantitativeparameters of renal allograft scintigraphyusing Tc99m-Ethylenedicystine.Methods: A total of 72 renal dynamicscintigraphic studies were performed within2-weeks of renal transplantation in 42patients. The graft perfusion, kidney/aortaratio, washout index and retention index werederived from all studies. All these parameterswere evaluated for their ability to distinguishbetween a normal graft, a graft with acuterejection (AR), and a graft with acute tubularnecrosis (ATN). Histopathological verificationof diagnosis was obtained in all cases.Results: Studies were subdivided into 3groups according to histopathological findings:acute rejection (n = 42), normal (n = 18) andacute tubular necrosis (n = 12). Normalallografts were visualized with in2.66 ± 0.59 seconds of visualization ofabdominal aorta. The K/A ratio, wash out indexand retention index was 15.22 ± 6.86,1.67 ± 0.45, and 5.48 ± 0.98 respectively.Allografts with ATN were visualized with in3.36 ± 0.80 seconds of visualization ofabdominal aorta. The K/A ratio, wash out indexand retention index was 12.73 ± 6.74,0.60 ± 0.14, and 9.18 ± 1.48 respectively.In AR, allografts were visualized15.18 ± 9.48 seconds after visualization ofabdominal aorta. The K/A ratio, wash out indexand retention index was 7.07 ± 2.15,0.63 ± 0.11, and 2.26 ± 1.28 respectively.Conclusions: Retention index can separateall the three condition of normal, acuterejection and acute tubular necrosis from eachother. Retention index of <4 suggests acuterejection, a value between 4 and 7 suggestsnormal allograft and avalue of ≥7 is suggestive of acutetubular necrosis. However, perfusion, K/A ratioand washout index can not segregate all thethree groups.

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References

  1. Dubovsky EV, Logic JR, Diethelm AG, Balch CM, Tauxe WN. Comprehensive evaluation of renal function in the transplanted kidney. J Nucl Med 1975; 16: 1115–1120.

    Google Scholar 

  2. Kumar R, Bharathi Dasan J, Choudhury S, Guleria S, Padhy AK, Malhotra A. Scintigraphic patterns of lymphocele in postrenal transplant. Nucl Med Commun 2003; 24: 531–535.

    Google Scholar 

  3. Dubovsky EV, Russell CD, Erbas B. Radionuclide evaluation of renal transplants. Semin Nucl Med 1995; 25: 49–59.

    Google Scholar 

  4. Dubovsky EV, Russell CD, Bischof-Delaloye A, Bubeck B, Chaiwatanarat T, Hilson AJ et al. Radionuclide evaluation of renal transplants. Semin Nucl Med 1999; 25: 175–188.

    Google Scholar 

  5. Taylor A Jr, Eshima D, Fritzberg AR, Christian PE, Kasina S. Comparison of iodine-131-OIH and Technetium-99m-MAG3 renal imaging in volunteers. J Nucl Med 1986; 27: 795–803.

    Google Scholar 

  6. Stabin M, Taylor A, Eshima D, Wotten W. Radiation dosimetry of Technetium-99m-MAG3, Technetium-99m-DTPA and iodine-131-OIH based on human biodistribution studies. J Nucl Med 1992; 33: 33–40.

    Google Scholar 

  7. Kabasakal L, Atay S, Vural VA, Ozker K, Sonmezoglu K, Demir M et al. Evaluation of Tc-99m-L,L-ethylenedicystine in renal disorders and determination of extraction ratio. J Nucl Med 1995; 36: 1398–1403.

    Google Scholar 

  8. Taylor A Jr, Eshima D, Christian PE, Wooten WW, Hansen L, McElvany K. A technetium-99m-MAG3-kit formulation: preliminary results in normal volunteers and patients with renal failure. J Nucl Med 1988; 29: 616–622.

    Google Scholar 

  9. Preston DF, Luke RG. Radionuclide evaluation of renal transplant. J Nucl Med 1979; 20: 1095–1097.

    Google Scholar 

  10. Hilson AJ, Maisey MN, Brown CB, Ogg CS, Bewick MS. Dynamic renal transplant imaging with Tc-99m-DTPA (Sn) suplmented by transplant perfusion index in the management of renal transplant. J Nucl Med 1978; 19: 994–1000.

    Google Scholar 

  11. Kiepfer RF, Kirchner PT, Gerber FH. Clinical application of Kidney to aortic blood flow index. J Nucl Med 1976; 17: 537–541.

    Google Scholar 

  12. Anaise D, Oster ZH, Atkins HL, Arnold AN, Weis S, Waltzer WC et al. Cortex perfusion index: a sensitive detector of acute rejection crisis in transplanted kidneys. J Nucl Med 1986; 27: 1697–1701.

    Google Scholar 

  13. Li Y, Russell CD, Palmer-Lawrence J, Dubovsky EV. Quantitation of renal parenhyal retention of technetium-99m-MAG3 in renal transplants. J Nucl Med 1994; 35: 846–850.

    Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

    Sukanta Barai, Rakesh Kumar, Sada Nand Mehta, Amit Kumar Dinda, Rajiv Yadav, Guru Pada Bandopadhayaya, Singhal Tarun & Arun Malhotra

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  1. Sukanta Barai
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  2. Rakesh Kumar
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  3. Sada Nand Mehta
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  4. Amit Kumar Dinda
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  5. Rajiv Yadav
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  6. Guru Pada Bandopadhayaya
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  7. Singhal Tarun
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  8. Arun Malhotra
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Correspondence to Sukanta Barai.

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Barai, S., Kumar, R., Mehta, S.N. et al. Diagnostic significance of semiquantitative and quantitative parameters of Tc99m-Ethylenedicystine renal allograft scintigraphy. Int Urol Nephrol 35, 451–456 (2003). https://doi.org/10.1023/B:UROL.0000025623.36472.d8

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  • DOI: https://doi.org/10.1023/B:UROL.0000025623.36472.d8

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