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Radiocontrast-induced nephrotoxicity and urinary alpha-glutathione S-transferase levels: Effect of amlodipine administration

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Abstract

Aims: The exact pathogenesis and prophylaxis concerning radiocontrast-induced nephrotoxicity (RCIN) was unclear. Short-acting calcium antagonists were used to prevent RCIN. This study was designed to evaluate the role of a long-acting calcium antagonist (amlodipine) administration by determining serum creatinine (SCre) levels and 24 hour urinary excretion rates of glutathione S-transferase alpha (GST-α) which has a selective localization only to proximal tubular epithelium.Methods: In a prospective trial, 29 outpatients (19 M, 10 F) undergoing coronary angiography were randomized and either amlodipine 10 mg/day (n = 15) or placebo (n = 14) were administered prior to angiography and continued thereafter. All patients had normal basal renal function and none of them had any risk factor for RCIN. A low osmolar, nonionic contrast media (iopamidol 76%) was administered to all patients. Creatinine clearance (CCre), SCre and 24-hour urinary GST-α levels were measured before, 24 hours and 7 days after angiography.Results: SCre and 24 hour urinary GST-α values increased on 24th hour following the angiography in both groups (p < 0.017 and 0.001, respectively). Pretreatment with amlodipine created no difference in both variables (p > 0.05).Conclusions: A reversible tubular dysfunction occurs following radiocontrast administration which was manifested by an increase in urinary GST-α excretion rates. Pretreatment with a long acting calcium antagonist amlodipine has no effect on the course of enzyme excretion and alteration observed in SCre

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Authors and Affiliations

  1. Department of Nephrology and Cardiology, Hacettepe University School of Medicine, Ankara, Turkey

    Mustafa Arıcı, Celalettin Usalan, Bülent Altun, Yunus Erdem, Ünal Yasavul, Çetin Turgan, Sırrı Kes & Şali Çağlar

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  1. Mustafa Arıcı
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  2. Celalettin Usalan
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  3. Bülent Altun
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Arıcı, M., Usalan, C., Altun, B. et al. Radiocontrast-induced nephrotoxicity and urinary alpha-glutathione S-transferase levels: Effect of amlodipine administration. Int Urol Nephrol 35, 256–261 (2003). https://doi.org/10.1023/B:UROL.0000020186.72345.ec

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  • DOI: https://doi.org/10.1023/B:UROL.0000020186.72345.ec

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