Abstract
Reformatsky reactions of ethyl α-bromopropionate, methyl α-bromobutyrate, and methyl α-bromo-isobutyrate with N-substituted 6-bromo-2-oxochromene-3-carboxamides in the system diethyl ether–benzene– HMPA give N-benzyl-6-bromo-4-(1-alkoxycarbonylalkyl)-2-oxochroman-3-carboxamides, while in the system diethyl ether–benzene–HMPA–THF, 3-R1-1-R2-1-R3-9-bromo-2,3,4,4a,5,10b-hexahydro-1H-chromeno[3,4-c]-pyridine-2,4,5-triones are obtained.
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Shchepin, V.V., Kalyuzhnyi, M.M., and Shchepin, R.V., Khim. Geterotsikl. Soedin., 2001, no. 10, p. 1415.
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Shchepin, V.V., Fotin, D.V., Fotin, V.V. et al. Reformatsky Reaction with N-Substituted 6-Bromo-2-oxochromene-3-carboxamides. Russian Journal of Organic Chemistry 40, 892–894 (2004). https://doi.org/10.1023/B:RUJO.0000044556.65215.ea
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DOI: https://doi.org/10.1023/B:RUJO.0000044556.65215.ea