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Synthesis and Study of Equilenin Derivatives and Modified Analogs

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Abstract

Modified equilenin analogs were synthesized with a view to examine the relation between the structure and biological properties of steroid estrogens. The 1H and 13C NMR signals of six estra-1,3,5,7,9-pentaenes were completely assigned using homo- and heteronuclear correlation NMR spectroscopy. The structure of equilenin methyl ester was determined by X-ray analysis. Among the synthesized steroids, compounds were found which exhibit hypocholesterinemic activity with no uterotropic and hypertriglyceridemic effects.

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Authors and Affiliations

  1. St. Petersburg State University, Universitetskii pr. 26, St. Petersburg, 198504, Russia

    E. A. Urusova, I. A. Gluzdikov, S. I. Selivanov, G. L. Starova, S. V. Nikolaev & A. G. Shavva

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  1. E. A. Urusova
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  2. I. A. Gluzdikov
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  3. S. I. Selivanov
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  4. G. L. Starova
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  5. S. V. Nikolaev
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  6. A. G. Shavva
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Urusova, E.A., Gluzdikov, I.A., Selivanov, S.I. et al. Synthesis and Study of Equilenin Derivatives and Modified Analogs. Russian Journal of Organic Chemistry 40, 506–512 (2004). https://doi.org/10.1023/B:RUJO.0000036071.26335.eb

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