Abstract
According to the X-ray diffraction data, the major isomer of 1-(N-benzoyl-β-alanyloxy)-4-benzoyl-oxyadamantane obtained by esterification of β-alanine with 5-hydroxyadamantan-2-one and subsequent benzoylation has trans configuration. The trans–cis isomer ratio is 2:1. A similar isomer ratio was found for 1-(N-benzoylphenylisoseryloxy)-4-benzoyloxyadamantane synthesized by an analogous method.
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Zefirova, O.N., Nurieva, E.V., Chekhlov, A.N. et al. Synthetic Approaches to Physiologically Active Polycyclic Compounds: IV. X-Ray Diffraction Study of Isomeric Amino Acid Derivatives of Adamantane. Russian Journal of Organic Chemistry 40, 502–505 (2004). https://doi.org/10.1023/B:RUJO.0000036070.38148.e7
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DOI: https://doi.org/10.1023/B:RUJO.0000036070.38148.e7