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Synthesis of Cationic Cholesterol Derivatives with Fragments of Aliphatic Nitrogen-Containing Bases

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Abstract

Cationic cholesterol derivatives were synthesized, in which fragments of aliphatic amines (2-di-methylaminoethanol, N,N-dimethylethylenediamine, and N,N,N',N'-tetramethylethylenediamine) are attached to the cholesterol backbone either directly or through a spacer ester or carbamate moiety. The products may be used as efficient agents for liposome-mediated transfection.

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Authors and Affiliations

  1. Lomonosov Moscow State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia

    T. V. Sokolova, Yu. S. Klesareva & G. A. Serebrennikova

Authors
  1. T. V. Sokolova
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  2. Yu. S. Klesareva
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  3. G. A. Serebrennikova
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Sokolova, T.V., Klesareva, Y.S. & Serebrennikova, G.A. Synthesis of Cationic Cholesterol Derivatives with Fragments of Aliphatic Nitrogen-Containing Bases. Russian Journal of Organic Chemistry 40, 334–336 (2004). https://doi.org/10.1023/B:RUJO.0000034966.03875.de

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  • DOI: https://doi.org/10.1023/B:RUJO.0000034966.03875.de

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