Abstract
Direct oxidation of o-(arylmethyl)benzoic acids with sodium peroxysulfate-copper(II) chloride in water yields γ-substituted phthalides. The reaction is highly regioselective, and the corresponding γ-butyrolactones are the only products formed through intermediate stable arylmethyl radicals.
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Mahmoodi, N.O., Salehpour, M. Direct Synthesis of γ-Substituted Phthalides by Cyclization of Benzyl Radicals Generated from o-(Arylmethyl)benzoic Acids*. Russian Journal of Organic Chemistry 39, 1760–1763 (2003). https://doi.org/10.1023/B:RUJO.0000019740.66204.fa
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DOI: https://doi.org/10.1023/B:RUJO.0000019740.66204.fa