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Variation of Xantphos-Based Ligands in the Palladium-Catalyzed Reaction of Aryl Halides with Ureas

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Abstract

A series of Xantphos-based ligands containing various substituents in the diphenylphosphino groups were synthesized, and their effect on the product yield and ratio in the palladium-catalyzed arylation of ureas with nonactivated aryl halides was studied. The arylation of urea and phenylurea in the presence of Pd2(dba)3-CHCl3, 3,5-(CF3)2Xantphos, and Cs2CO3 in dioxane at 100°C gave the corresponding N,N'-diarylureas in 62-98% yield.

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Leninskie gory 1, Moscow, 119992, Russia

    A. G. Sergeev, G. A. Artamkina & I. P. Beletskaya

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  1. A. G. Sergeev
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  2. G. A. Artamkina
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  3. I. P. Beletskaya
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Sergeev, A.G., Artamkina, G.A. & Beletskaya, I.P. Variation of Xantphos-Based Ligands in the Palladium-Catalyzed Reaction of Aryl Halides with Ureas. Russian Journal of Organic Chemistry 39, 1741–1752 (2003). https://doi.org/10.1023/B:RUJO.0000019738.50339.e8

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