Skip to main content
SpringerLink
Log in

Epidemiology of Congenital Malformations in Gorno-Altaisk, Altai Republic, Russia

  • Published:
Russian Journal of Genetics Aims and scope Submit manuscript

Abstract

A retrospective epidemiological study has been performed using the data from healthcare institutions of the city of Gorno-Altaisk, Altai Republic, Russia for the period from 1983 to 2001. Congenital malformations (CMFs) have been studied in newborns, infants that died at ages under one year, and fetuses after 22 weeks of gestation. The most frequent malformations are those of the musculoskeletal and cardiovascular systems and multiple malformations, which account for 37.68, 18.22, and 8.9% of all congenital malformations, respectively. Their frequencies are 7.38, 3.57, and 1.74‰, respectively. The frequency of congenital malformations subject to registration by the national system of CMF monitoring of the Russian Federation (21 malformation forms) is 6.08 per 1000 births and varies from 8.59 to 21.24. The frequency of the Down syndrome is 0.93 per 1000 births; it did not vary significantly during the period studied. The frequency of limb reduction deformities in the urban population of Altai Republic (0.32 per 1000 births) is higher than in other Siberian regions, including the cities of Kyzyl (Tyva Republic) and Tomsk and the Nyurba and Ust-Aldan uluses of Sakha Republic (Yakutia)

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Genetika i meditsina (Genetics and Medicine), Bochkov, N.P., Ed., Moscow: Meditsina, 1979.

    Google Scholar 

  2. Dubinin, N.P., Nekotorye problemy sovremennoi genetiki (Selected Problems of Modern Genetics), Moscow: Nauka, 1994.

    Google Scholar 

  3. Puzyrev, V.P., Genetic Demographic Events and Ecological Stress in the Siberian Population, Sib. Ekol. Zh., 1994, no. 2, pp. 101-102.

  4. Ginter, E.K. and Petrin, A.N., The Role of Inbreeding and Its Structure in the Load of Hereditary Disorders on Human Populations, in Profilaktika nasledstvennykh boleznei (Prevention of Hereditary Disorders), Moscow: Meditsina, 1987, pp. 88-102.

    Google Scholar 

  5. Bochkov, N.P. and Katosova, L.D., Genetic Monitoring in Human Populations Exposed to Chemical Factors or Radiation, Vestn. Rus. Akad. Med. Nauk., 1992, no. 4, pp. 10-14.

  6. Kontseptual’naya programma ekologicheski ustoichivogo razvitiya Respubliki Altai (A Conceptual Program of Ecologically Stable Development of the Altai Republic), Gorno-Altaisk, 1998, pp. 47-48.

  7. Baeva, L.N., Ekonomicheskaya i sotsial’naya geografiya Altaiskogo regiona (Economical and Social Geography of the Altaian Region), Gorno-Altaisk: Otd. Operat. Poligraf. Gorno-Altaisk. Gos. Univ., 1994.

    Google Scholar 

  8. Altukhov, Yu.P., Geneticheskie protsessy v populyatsiyakh (Genetic Processes in Populations), Moscow: Nauka, 1989.

    Google Scholar 

  9. Nikolaeva, I.V., The Use of Retrospective Recording of Congenital Malformations in the System of Genetic Monitoring, Cand. Sci. (Med.) Dissertation, Moscow: Inst. Med. Genet., 1986.

    Google Scholar 

  10. Kallen, B., Population Surveillance of Congenital Malformations: Possibilities and Limitation, Acta Pediatr. Scand., 1989, vol. 78, pp. 657-663.

    Google Scholar 

  11. Calzolari, E., Bianchi, F., Dolk, H., et al., Congenital Malformations in 100000 Consecutive Births in Emilia Romagna Region of Northern Italy: Comparison with the EUROCAT Data, Eur. J. Epidemiol., 1987, vol. 3, pp. 423-430.

    Google Scholar 

  12. EUROCAT, Surveillance of Congenital Anomalies, 1980-1990, Rome: EUROCAT Work., 1993, p. 141.

    Google Scholar 

  13. Bochkov, N.P., Podunova, L.G., Zhuchenko, N.A., et al., Monitoring vrozhdennykh porokov razvitiya. Metodicheskie rekomendatsii (Monitoring of Congenital Malformations: Methodical Recommendations), Moscow: Goskomsanepidnadzor RF, 1996.

    Google Scholar 

  14. Krikunova, N.I., Nazarenko, L.P., and Shapran, N.V., Dynamics of Congenital Malformations by Data of the Tomsk Genetic Register, Genetika cheloveka i patologiya (Human Genetics and Pathology), Tomsk, 2002, issue 6, pp. 80-86.

  15. Puzyrev, V.P., Erdynieva, L.S., Kucher, A.N., and Nazarenko, L.P., Genetiko-epidemiologicheskoe issledovanie naseleniya Tuvy (A Genetic Epidemiological Study of the Tuva Population), Tomsk, 1999, pp. 203-217.

  16. Nazarenko, L.P., Nazarenko, S.A., Kirillina, V.I., and Prokop’eva, Yu.N., Genetiko-ekologicheskaya otsenka sostoyaniya zdorov’ya zhitelei Yakutii (Genetic Ecological Evaluation of the State of Health in the Population of Yakutia), Yakutsk, 2001, pp. 48-65.

Download references

Author information

Authors and Affiliations

  1. Research Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, 634050, Russia

    N. I. Krikunova, L. I. Minaicheva, L. P. Nazarenko, S. V. Fadyushina & N. V. Shapran

  2. Republic Children Hospital, Gorno-Altaisk, 659700, Altai Republic, Russia

    V. N. Tadinova & V. V. Nesterova

Authors
  1. N. I. Krikunova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. I. Minaicheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. P. Nazarenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. N. Tadinova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Nesterova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. V. Fadyushina
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. V. Shapran
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krikunova, N.I., Minaicheva, L.I., Nazarenko, L.P. et al. Epidemiology of Congenital Malformations in Gorno-Altaisk, Altai Republic, Russia. Russian Journal of Genetics 40, 932–937 (2004). https://doi.org/10.1023/B:RUGE.0000039728.91864.f6

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:RUGE.0000039728.91864.f6

Keywords

Search

Navigation