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Regioselective C-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones

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Abstract

Regioselective C- or O-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones is possible, depending on the solvent nature. A convenient preparative method of C-alkylation was proposed and previously not easily accessible β-hydroxythiophene derivatives were synthesized.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    M. M. Krayushkin, V. Z. Shirinian, D. M. Nikalin & A. A. Shimkin

Authors
  1. M. M. Krayushkin
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  2. V. Z. Shirinian
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  3. D. M. Nikalin
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  4. A. A. Shimkin
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Krayushkin, M.M., Shirinian, V.Z., Nikalin, D.M. et al. Regioselective C-alkylation of alkyl 4-hydroxy-2-methylthiophene-3-carboxylates with α-halo ketones. Russian Chemical Bulletin 53, 631–634 (2004). https://doi.org/10.1023/B:RUCB.0000035648.41262.77

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  • DOI: https://doi.org/10.1023/B:RUCB.0000035648.41262.77

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