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Cross-condensation of derivatives of cyanoacetic acid and carbonyl compounds. 2. One-pot synthesis of substituted 2-amino-7-methyl-5-oxo-4,5-dihydropyrano[4,3-b]pyrans in ethanol and ionic liquid [bmim][PF6]

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Abstract

The three-component reaction of 4-hydroxy-6-methylpyran-2(2H)-one with cyanoacetic acid derivatives and carbonyl compounds in EtOH or in the ionic liquid, viz., 1-butyl-3-methylimidazolinium hexafluorophosphate ([bmim][PF6]), affords substituted 2-amino-7-methyl-5-oxo-4,5-dihydropyrano[4,3-b]pyrans. The yield of substituted pyrano[4,3-b]pyrans in [bmim][PF6] is by 10—14% higher than that in EtOH.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. M. Shestopalov, S. G. Zlotin, A. A. Shestopalov, V. Yu. Mortikov & L. A. Rodinovskaya

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  1. A. M. Shestopalov
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  2. S. G. Zlotin
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  3. A. A. Shestopalov
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  4. V. Yu. Mortikov
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  5. L. A. Rodinovskaya
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Shestopalov, A.M., Zlotin, S.G., Shestopalov, A.A. et al. Cross-condensation of derivatives of cyanoacetic acid and carbonyl compounds. 2. One-pot synthesis of substituted 2-amino-7-methyl-5-oxo-4,5-dihydropyrano[4,3-b]pyrans in ethanol and ionic liquid [bmim][PF6]. Russian Chemical Bulletin 53, 573–579 (2004). https://doi.org/10.1023/B:RUCB.0000035640.47443.a4

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  • DOI: https://doi.org/10.1023/B:RUCB.0000035640.47443.a4

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