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Acyclic Nucleoside Analogues: III. A Synthesis of New 2′,3′-Dideoxy-2′,3′-Didehydronucleoside Analogues

Russian Journal of Bioorganic Chemistry volume 30, pages 547–552 (2004)Cite this article

Abstract

The coupling of 5-acetoxy-1,1-dimethoxypent-2-ene with cytosine and thymine trimethylsilyl derivatives, as well as the reaction of 5-acetoxy-1-bromopent-2-ene with adenine sodium salt, yielded acyclic analogues of the corresponding nucleosides containing 5′-acetoxy groups. They were deprotected with a saturated methanolic solution of ammonia to the target analogues of nucleosides, which were characterized with 1H NMR, IR, and UV spectra.

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Authors and Affiliations

  1. National Research Center of Antibiotics, Nagatinskaya ul. 3A, Moscow, 117105, Russia

    I. A. Vasilenko & D. V. Shamshin

  2. Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia

    A. V. Tsytovich, A. N. Kan, S. G. Alekseeva & V. I. Shvets

Authors
  1. I. A. Vasilenko
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  2. D. V. Shamshin
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  3. A. V. Tsytovich
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  4. A. N. Kan
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  5. S. G. Alekseeva
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  6. V. I. Shvets
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Vasilenko, I.A., Shamshin, D.V., Tsytovich, A.V. et al. Acyclic Nucleoside Analogues: III. A Synthesis of New 2′,3′-Dideoxy-2′,3′-Didehydronucleoside Analogues. Russian Journal of Bioorganic Chemistry 30, 547–552 (2004). https://doi.org/10.1023/B:RUBI.0000049771.66752.74

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  • DOI: https://doi.org/10.1023/B:RUBI.0000049771.66752.74

  • acyclic nucleoside analogues