Abstract
The coupling of 5-acetoxy-1,1-dimethoxypent-2-ene with cytosine and thymine trimethylsilyl derivatives, as well as the reaction of 5-acetoxy-1-bromopent-2-ene with adenine sodium salt, yielded acyclic analogues of the corresponding nucleosides containing 5′-acetoxy groups. They were deprotected with a saturated methanolic solution of ammonia to the target analogues of nucleosides, which were characterized with 1H NMR, IR, and UV spectra.
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Vasilenko, I.A., Shamshin, D.V., Tsytovich, A.V. et al. Acyclic Nucleoside Analogues: III. A Synthesis of New 2′,3′-Dideoxy-2′,3′-Didehydronucleoside Analogues. Russian Journal of Bioorganic Chemistry 30, 547–552 (2004). https://doi.org/10.1023/B:RUBI.0000049771.66752.74
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DOI: https://doi.org/10.1023/B:RUBI.0000049771.66752.74