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Synthesis and Antiaggregative Activity of a New RGDF Mimetic

Abstract

m-[4-Oxo-4-(piperazin-1-yl)butyrylamino)benzoyl-D,L-β-(3,4-methylenedioxyphenyl)-β-alanine, a new mimetic of the peptide RGDF, was synthesized. This compound inhibited ADP-induced platelet aggregation in human blood plasma enriched with platelets with IC50 = 3.5 × 10–8 M.

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Krysko, A.A., Malovichko, O.L., Kabanova, T.A. et al. Synthesis and Antiaggregative Activity of a New RGDF Mimetic. Russian Journal of Bioorganic Chemistry 30, 534–538 (2004). https://doi.org/10.1023/B:RUBI.0000049769.62906.0d

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  • DOI: https://doi.org/10.1023/B:RUBI.0000049769.62906.0d

  • GP IIb/IIIa
  • peptide synthesis
  • platelet aggregation
  • RGDF mimetic