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Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells

Russian Journal of Bioorganic Chemistry volume 30, pages 523–533 (2004)Cite this article

Abstract

Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc-strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time.

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REFERENCES

  1. Baggiolini, M., Nature, 1998, vol. 392, pp. 565–568.

    Google Scholar 

  2. Libby, P., J.Intern.Med., 2000, vol. 247, pp. 349–358.

    Google Scholar 

  3. Ross, R., Am.Heart J., 1999, vol. 138, pp. 419–420.

    Google Scholar 

  4. Rollins, B.L., Blood, 1997, vol. 90, pp. 909–928.

    Google Scholar 

  5. Yla-Herttuala, S., Lipton, B.A., Rosenfeld, M.E., Sarkioja, T., Yoshimura, T., Leonard, E.J., Wilzlum, J.L., and Steinberg, D., Proc.Natl.Acad.Sci.USA, 1991, vol.88, pp. 5252–5256.

    Google Scholar 

  6. Beall, C.J., Mahajan, S., Kuhn, D.E., and Kolat-tukudy, P.E., Biochem.J., 1996, vol. 313, pp. 633–640.

    Google Scholar 

  7. Gong, J.-H. and Clark-Levis, I., J.Exp.Med., 1995, vol.181, pp. 631–640.

    Google Scholar 

  8. Kaji, M., Ikari, M., Hashiguchi, S., Ito, Y., Mastsumoto, R., Yoshimura, T., Karatsb, J., and Sugimura, K., J.Biochem., 2001, vol. 129, pp. 577–583.

    Google Scholar 

  9. Steitz, S.A., Hasegawa, K., Chiang, S.-L., Cobb, R.R., Castro, M.A., Lobl, T.J., Yamada, M., Lazarides, E., and Cardarelli, P.M., FEBS Lett., 1998, vol. 430, pp. 158–164.

    Google Scholar 

  10. Reckleess, J. and Grainger, D.J., Biochem.J., 1999, vol.340, pp. 803–811.

    Google Scholar 

  11. Valente, A.J., Rozek, M.M., Schwartz, C.J., and Graves, D.T., Biochem.Biophys.Res.Commun., 1991, vol. 176, pp. 309–314.

    Google Scholar 

  12. Reckleess, J., Tatalick, L.M., and Grainger, D.J., Immunology, 2001, vol. 103, pp. 1–17.

    Google Scholar 

  13. Shemyakin, M.M., Ovchinnikov, Yu.A., and Ivanov, V. T., Angew.Chem., Int.Ed.Engl., 1969, vol. 8, pp. 492–499.

    Google Scholar 

  14. Andreu, D., Albericio, F., Sole, N.A., Munson, M.C., Ferrer, M., and Barany, G., in Peptide Synthesis Protokols, Pennington, W. and Dunn, M.B., Eds.., Totowa, NJ: Humana, 1994, pp. 91–169.

    Google Scholar 

  15. Fields, G.B. and Noble, R.L., Int.J.Pept.Protein Res., 1990, vol. 35, pp. 161–214.

    Google Scholar 

  16. Walker, B., in Peptide Antigens, Wisdom, G.B., Ed. Oxford, UK: IRL, 1994, pp. 27–81.

    Google Scholar 

  17. Siber, P., Tetrahedron Lett., 1987, vol. 28, pp. 1637–1640.

    Google Scholar 

  18. Rubina, A.Yu., Bespalova, Zh.D., Ovchinnikov, M.V., Bushuev, V.N., Popletaeva, E.B., and Efremov, E.E., Mendeleev Commun., 1996, pp. 159–161.

  19. Wüthrich, K., NMR of Proteins and Nucleic Acids, New York: Wiley, 1986.

    Google Scholar 

  20. Lauer, J.L., Fields, C.G., and Fields, G.B., Lett.Peptide Sci., 1994, vol. 1, pp. 197–205.

    Google Scholar 

  21. Nicolas, E., Pedroso, E., and Giralt, E., Tetrahedron Lett., 1989, vol. 30, pp. 497–500.

    Google Scholar 

  22. Dolling, R., Beyermann, M., Haenel, J., Kernchen, F., Krause, E., Franke, P., Brudel, M., and Bienert, M., J.Chem.Soc., Chem.Commun., 1994, pp. 853–854.

  23. Sidorova, M.V., Molokoedov, A.S., Az'muko, A.A., Kudryavtseva, E.V., Krauze, E., Ovchinnikov, M.V., and Bespalova, Zh.D., Bioorg.Khim., 2004, vol. 30, pp. 115–125.

    Google Scholar 

  24. Han, K.H., Green, S.R., Tangirala, R.K., Tanaka, S., and Quenhenberger, O., J.Biol.Chem., 1999, vol. 274, pp.32 055–32 062.

    Google Scholar 

  25. Jarnagin, K., Grunberger, D., Mulkins, M., Wong, B., Hemmerich, S., Paavola, C., Bloom, A., Bhakta, S., Diehl, F., Freedman, R., McCarley, D., Polsky, I., Ping-Tsou, A., Kosaka, A., and Handel, T.M., Biochemistry, 1999, vol. 38, pp. 16 167–16 177.

    Google Scholar 

  26. Boyum, A., Scand.J.Clin.Lab.Invest.Suppl., 1968, pp.77–89.

  27. Vitt, S.V., Myagkova, M.A., Saporovskaya, M.B., Nikitina, S.B., and Belikov, V.M., Bioorg.Khim., 1978, vol. 4, pp. 154–157.

    Google Scholar 

  28. Al-Sumidaie, A.M., Jones, D.L., and Young, H.L., J.Immunol.Methods, 1984, vol. 75, pp. 129–140.

    Google Scholar 

  29. Falk, W., Goodwin, R.H., and Leonard, E.J., J.Immunol.Methods, 1980, vol. 33, pp. 239–247.

    Google Scholar 

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Authors and Affiliations

  1. Cardiological Research and Production Association, Ministry of Health of the Russian Federation, ul. Tret'ya Cherepkovskaya 15a, Moscow, 121552, Russia

    M. V. Sidorova, A. S. Molokoedov, T. I. Aref'eva, N. B. Kukhtina, T. L. Krasnikova, Zh. D. Bespalova & V. N. Bushuev

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  1. M. V. Sidorova
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  2. A. S. Molokoedov
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  3. T. I. Aref'eva
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  4. N. B. Kukhtina
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  5. T. L. Krasnikova
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  6. Zh. D. Bespalova
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  7. V. N. Bushuev
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Sidorova, M.V., Molokoedov, A.S., Aref'eva, T.I. et al. Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells. Russian Journal of Bioorganic Chemistry 30, 523–533 (2004). https://doi.org/10.1023/B:RUBI.0000049768.98894.f5

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  • DOI: https://doi.org/10.1023/B:RUBI.0000049768.98894.f5

  • chemokine MPC-1
  • monocytes
  • MCP-1-induced migration
  • solid phase peptide synthesis
  • synthetic peptides