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Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells

Abstract

Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc-strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time.

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Sidorova, M.V., Molokoedov, A.S., Aref'eva, T.I. et al. Peptide Fragments and Structural Analogues of Chemokine MCP-1: Synthesis and Effect on the MCP-1-Induced Migration of Mononuclear Cells. Russian Journal of Bioorganic Chemistry 30, 523–533 (2004). https://doi.org/10.1023/B:RUBI.0000049768.98894.f5

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  • DOI: https://doi.org/10.1023/B:RUBI.0000049768.98894.f5

  • chemokine MPC-1
  • monocytes
  • MCP-1-induced migration
  • solid phase peptide synthesis
  • synthetic peptides