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A Liquid-Phase Synthesis of DNA-Binding Polyamides Using Oligocarboxamide Blocks

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Abstract

A method was developed for the synthesis of sequence-specific polyamides on the basis of 4-amino-1-methylpyrrole-2-carboxylic acid, 4-amino-1-methylimidazole-2-carboxylic acid, β-alanine, and γ-aminobutyric acid. Dimeric and trimeric oligocarboxamides were used as building blocks. Our synthetic scheme was applied for the synthesis of DNA minor groove binders containing up to twelve carboxamide units.

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Authors and Affiliations

  1. Vector State Research Center of Virology and Biotechnology, Institute of Molecular Biology, pos. Kol'tsovo, Novosibirsk oblast, 630559, Russia

    A. N. Sinyakov & V. A. Ryabinin

  2. Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent'eva 8, Novosibirsk, 630090, Russia

    M. V. Feshchenko

Authors
  1. A. N. Sinyakov
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  2. M. V. Feshchenko
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  3. V. A. Ryabinin
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Correspondence to V. A. Ryabinin.

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Sinyakov, A.N., Feshchenko, M.V. & Ryabinin, V.A. A Liquid-Phase Synthesis of DNA-Binding Polyamides Using Oligocarboxamide Blocks. Russian Journal of Bioorganic Chemistry 30, 98–99 (2004). https://doi.org/10.1023/B:RUBI.0000015781.35511.aa

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  • DOI: https://doi.org/10.1023/B:RUBI.0000015781.35511.aa

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