Skip to main content

Effects of parsley (Petroselinum crispum) on the aorta and heart of Stz induced diabetic rats

Plant Foods for Human Nutrition volume 58, pages 1–7 (2003)Cite this article

Abstract

Parsley is one of the medicinal herbs used by diabetics in Turkey. It has been reported to reduce blood glucose levels. In this study the effects of feeding parsley on diabetes-induced free radical mediated injury in rat aorta and heart tissues were investigated. Swiss albino rats were divided into six groups: Control, diabetic, parsley, diabetic + parsley, glibornurid, and diabetic + glibornurid. Rats were subjected to i.p. streptozotocin (STZ, 65 mg/kg) to induce diabetes. On the fourteenth day of the study, either parsley (2 g/kg) or glibornurid (5 mg/kg) were given for 28 days to the diabetic rats. Aorta and heart tissue lipid peroxidation and glutathione levels as well as blood glucose levels were determined. The results of the present study indicate that lipid peroxidation was increased and glutathione levels were decreased in both aorta and heart tissue of the diabetic rats. However, treatment of the diabetic rats with either parsley or glibornurid reversed the effects of diabetes on blood glucose, and tissue lipid peroxidation and glutathione levels.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price includes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. Wohaieb SA, Godin DV (1987) Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Diabetes 36: 1014–1018.

    PubMed  Google Scholar 

  2. Yki-Jarvinen H (2000) Management of type 2 diabetes mellitus and cardiovascular risk: lessons from intervention trials. Drugs. 60(5): 975–983.

    PubMed  Google Scholar 

  3. Ivorra MD, Paya M, Villar A (1989) A review of natural products and plants as potential antidi-abetic drugs. J Ethnopharmacol 27: 243–275.

    PubMed  Google Scholar 

  4. Yazicioğlu A, Tuzlaci E (1996) Folk medicinal plants of Trabzon (Turkey). Fitoterapia LXVII 4: 307–318.

    Google Scholar 

  5. Manderfeld MM, Schafer HW, Davidson PM, Zottola EA (1997) Isolation and identification of antimicrobial furocoumarins from parsley. J Food Prot 60: 72–77.

    PubMed  Google Scholar 

  6. Baytop T 1(984) Türkiyéde Bitkiler ile Tedavi, Istanbul üniversitesi yayinlari No. 3255 Ecz. Fak. No. 40, İstanbul, 461–467.

  7. Öztürk Y, Başer KHC, Aydin S (1991) Hepatoprotective (antihepatotoxic) plants in Turkey. In Proceedings of the 9th Symposium on Plant Drugs (16-19 May Eski¸ sehir, Turkey), pp 40–50.

  8. Merzouki A, Ed-Derfoufi F, El-Aallall A, Molero-Mesa J (1997) Wild medicinal plants used by local Bouhmed population (Morocco). Fitoterapia LXVIII 5: 444–460.

    Google Scholar 

  9. Hahlbrock K (1981) Flavanoids. Biochem Plant 7: 549–551.

    Google Scholar 

  10. Anand NK, Sharma ND, Gupta SR (1981) Coumarins from Apium petroselinum seeds. Natl Acad Sci Lett 4: 249–251

    Google Scholar 

  11. Simon JE, Quinn J (1988) Characterization of essential oil of parsley. J Agric Food Chem 36: 467–471.

    Google Scholar 

  12. Francis GW, Isaksen M (1989) Droplet counter current chromatography of the carotenoids of parsley Petroselinum crispum. Chromatographia 27: 549–551.

    Google Scholar 

  13. Lamarti A, Badoc A, Bouriquet R (1991) A chemotaxonomic evaluation of Petroselinum crispum (Mill.) A. W. Hill (parsley) marketed in France. J Essent Oil Res 3: 425–433.

    Google Scholar 

  14. Spraul MH, Nitz S, Drawert F (1991) The chemical composition of parsley root and seed extracts. Chem Microbiol Technol Lebensm 13: 179–182.

    Google Scholar 

  15. Davey MW, Bauw G, Montagu MV (1996) Analysis of ascorbate in plant tissue by high perfor-mance capillary zone electrophoresis. Anal Biochem 239: 8–19.

    PubMed  Google Scholar 

  16. Cohen AM, Yanko L, Rosenmann E (1983) Control of blood glucose levels and development of diabetic microangiopathy: Effect of glibornurid. Isr J Med Sci 19: 311–8.

    PubMed  Google Scholar 

  17. Relander A, Raiha CE (1963) Differences between the enzymatic and toluidine methods of blood glucose determination. Scand J Clin Lab Invest 15: 221–224.

    Google Scholar 

  18. Beuge JA, Aust SD (1978). Microsomal lipid peroxidation. Methods in Enzymology 52: 302–311.

    PubMed  Google Scholar 

  19. Beutler E (1975) Glutathione in red blood cell metabolism. A Manuel of Biochemical Methods, Grune & Stratton, New York, pp 112–114.

    Google Scholar 

  20. Aiello LP, Wong JS (2000) Role of vascular endothelial growth factor in diabetic vascular com-plications. Kidney Int 58 (Suppl 77): 113–119.

    Google Scholar 

  21. Shah G, Pinnas JL, Lung CC, Mahmoud S, Mooradian AD (1994) Tissue specific distrubition of malondialdehyde modified proteins in diabetes mellitus. Life Sci 55(17): 1343–1349.

    PubMed  Google Scholar 

  22. Fukui T, Noma T, Mizushige K, Aki Y, Kimura S, Abe Y (2000) Dietary troglitazone decreases oxidative stress in early stage type II diabetic rats. Life Sci 66 (21): 2043–2049.

    PubMed  Google Scholar 

  23. Rauscher FM, Sanders RA, Watkins JB (2000) Effects of new antioxidant compounds PNU-104067F and PNU-74389G on antioxidant defense in normal and diabetic rats. J Biochem Mol Toxicol 14(4): 189–194.

    PubMed  Google Scholar 

  24. Schiekofer S, Balletshofer B, Andrassy M, Bierhaus A, Nawroth PP (2000) Endothelial dysfunc-tion in diabetes mellitus. Semin Thromb Hemostasis 26(5): 503–511.

    Google Scholar 

  25. Kesavulu MM, Giri R, Kameswara RB, Apparao C (2000) Lipid peroxidation and antioxidant enzyme levels in type 2 diabetes with microvascular complications. Diabetes Metabol 26(5): 387–392.

    Google Scholar 

  26. Chugh SN, Kakkar R, Kalra S, Sharma A (1999) An evaluation of oxidative stress in diabetes mellitus during uncontrolled and controlled state and after vitamin E supplementation. J Assoc Physicians Ind 47(4): 380–383.

    Google Scholar 

  27. Tomoda M, Shimada K, Konno C, Hikino H (1985). Structure of Panaxan B. A hypoglycaemic glycan of panax ginseng roots. Phytochemistry 24: 2431–2433.

    Google Scholar 

  28. Shimizu M, Ito T, Terashima S, Mayashi T, Arisawa M, Morita N, Kurokowa S, Ito K, Hasimato Y (1984) Inhibition of lens aldose reductase by flavonoids. Phytochemistry 23: 1885–1888.

    Google Scholar 

  29. Hikino H, Kobayashi M, Suzuki Y, Konno C (1989) Mechanisms of hypoglycemic activity of aconitan A, a glycan from Acanitum carmichaeli roots. J Ethnopharmacol 25: 295–304.

    PubMed  Google Scholar 

  30. Khanna P, Jain SC (1981) Hypoglycemic activity of polypeptide-p from a plant source. J Nat Product 44: 648–655.

    Google Scholar 

  31. Reher G, Slijepcevic M, Kraus L (1991) Hypoglcemic activity of triterpenes and tannins from Sarcopoterium Spinosum and two Sanguisorbia species. Planta Med 57: A57–A58.

    Google Scholar 

  32. Karawya MS, Wahab SAA (1984) Diphenylamine, an antihyperglycemic agent from onion and tea. J Nat Product 47: 775–780.

    Google Scholar 

  33. Ng TB, Liu F, Wang ZT (2000) Antioxidative activity of natural products from plants. Life Sci 66(8): 709–723.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmacy, Marmara University, 81010, İstanbul-Turkey

    Göksel Sener & Gül Ayanoglu-Dülger

  2. Department of Chemistry, Faculty of Engineering, İstanbul University, 34850, Avcı, İstanbul-Turkey

    Özlem Saçan & Refiye Yanardag

Authors
  1. Göksel Sener
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Özlem Saçan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Refiye Yanardag
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gül Ayanoglu-Dülger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sener, G., Saçan, Ö., Yanardag, R. et al. Effects of parsley (Petroselinum crispum) on the aorta and heart of Stz induced diabetic rats. Plant Foods Hum Nutr 58, 1–7 (2003). https://doi.org/10.1023/B:QUAL.0000041152.24423.bb

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:QUAL.0000041152.24423.bb

  • glutathione
  • lipid peroxidation
  • parsley
  • streptozotocin