In the present study, the cardioprotective action of tender coconut water (TCW) in experimental myocardial infarction induced by isoproterenol in rats was studied. The results indicated that feeding TCW afforded protection against induction of myocardial infarction. There was decreased concentration of total cholesterol, VLDL + LDL− cholesterol and HDLcholesterol in the serum of isoproterenol treated rats fed TCW. The cholesterol levels in the heart and aorta were also lower in these groups. Triglycerides and phospholipids in the serum, heart and aorta were lower in isoproterenol treated rats given TCW. Recovery from myocardial damages was evident from the values of marker enzymes viz creatine phosphokinase (CPK), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH). Induction of myocardial infarction in rats by isoproterenol administration resulted in increased activities of SGOT, SGPT and LDH in the serum and heart and CPK in the serum. On the other hand, isoproterenol treated rats fed TCW showed decreased activities of these enzymes. Histopathological studies showed very little myocardial damage in isoproterenol treated rats fed TCW. The observed beneficial effects of TCW may be due to several factors viz potassium, calcium, magnesium, L-arginine that are present in the water.
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Anurag, P., Rajamohan, T. Cardioprotective effect of tender coconut water in experimental myocardial infarction. Plant Foods Hum Nutr 58, 1–12 (2003). https://doi.org/10.1023/B:QUAL.0000040363.64356.05
- Creatine phosphokinase
- Lactate dehydrogenase
- Myocardial infarction
- Tender coconut water