Plant Foods for Human Nutrition

, Volume 58, Issue 3, pp 1–11 | Cite as

Reduction of dimethylhydrazine-induced cytotoxicity by mango fruit bar: Changes in antioxidant enzymes in rats

  • K.R. Anilakumar
  • F. Khanum
  • K.R.S. Krishna
  • K. Santhanam


Male Wistar rats were fed the control casein diet, 10% mango fruit bar (MFB) substituted casein diet and 20% MFB substituted casein diet for 12 weeks. Dimethylhydrazine (DMH) was coadministered weekly (s.c) to another 3 groups of rats maintained on the same diets. At the end of the experimental period the rats were sacrificed. The results revealed that the ingestion of the processed mango fruit altered the DMH-induced reduced catalase activity in the liver. However, MFB did not elicit any effect on the induced peroxidative stress by DMH administration. The DMH exposure increased the kidney GGT and femur micronuclei and the fruit bar consumption reduced it. The MFB feeding also increased hepatic vitamin A and glutathione-S-transferase (GST) activitiy. The study suggested that the long term consumption of the processed mango fruit may have significant inhibitory effects on the cytotoxicity of DMH in rats.

Antioxidant enzymes DMH GGT Mango fruit bar Micronuclei 


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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • K.R. Anilakumar
    • 1
  • F. Khanum
    • 1
  • K.R.S. Krishna
    • 1
  • K. Santhanam
    • 1
  1. 1.Biochemistry and Nutrition DisciplineDefence Food Research LaboratoryMysoreIndia

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