Plant Foods for Human Nutrition

, Volume 58, Issue 3, pp 1–7 | Cite as

Hypoglycemic potentials of methanolic extracts of selected plant foods in alloxanized mice

  • O.O. Ogundipe
  • J.O. Moody
  • T.O. Akinyemi
  • A. Raman


Crude methanolic extracts of five selected edible plant foods were tested for hypoglycemic activity in alloxanized mice. Fasting blood sugar levels were reduced significantly at differing rates. The order of their antidiabetic activity were H. sabdariffa, A. occidentalis, S. americanum, V. amygdalina, G. latifolium, H. sabdariffa, A. occidentalis and S. americanum, utilized at a dose of 100 mg/kg, had similar activity as chlorpropamide (5 mg/kg), which was used as a reference standard, in that they reduced blood sugar levels in mice below the initial values.

Alloxanized mice Hypoglycemic activity Plant foods 


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  1. 1.
    McCarthy D, Zinnet P (1994) Diabetes, 1994–2000. Global estimates and projections. International diabetes Institute, Melbourne.Google Scholar
  2. 2.
    Mazze RS (1994) A systematic approach to diabetes cure. Diabetes cure 17: 5–11.Google Scholar
  3. 3.
    Hammouda Y, Amer MS (1996) Antidiabetic effect of tecomine and tecostamine. J Pharm Sci 55: 1452–1454.Google Scholar
  4. 4.
    Barley CJ, Nattrass M (1988) Non-insulin Dependent Diabetes Mellitus. In Nattrass M, Hale PJ (eds), Treatment with Metformin, Clinical Endocrinology and Metabolism. London: Bailliere-Tindall, pp 455–476.Google Scholar
  5. 5.
    WHO Expert Committee (1980) Diabetes Mellitus, 2nd Rep. Geneva, World Health Organisation (Technical Rep. Ser.), p 646.Google Scholar
  6. 6.
    Olapade EO (1995) Food and Herbs on Diabetes Mellitus NARL specialist. Clinical publications, Ibadan, pp 1–5.Google Scholar
  7. 7.
    Tindall HD (1983) Vegetables in the Tropics. The Macmillan company limited, London, UK.Google Scholar
  8. 8.
    Watt JM, Breyer-Brandwijk MG (1962) Medicinal and Poisonous Plants of Southern and Eastern Africa. UK: E & S Livingstone ltd.Google Scholar
  9. 9.
    Ogundipe OO, Moody JO, Oluwole FS, Fakeye TO (1999) Antiinflammatory and an-timicrobial activities of selected Nigerian plant foods. Proc 1st Int Workshop on the Standardization and Utilization of Herbal Medicines: Challenges of the 21st Century, University of Ibadan, pp 138–146.Google Scholar
  10. 10.
    Trease GE, Evans WC (1996) Pharmacognosy, 14th Edition, London: W.B. Saunders.Google Scholar
  11. 11.
    Abo KA, Okoko OO (1999) Hypoglycemic effect of Tecoma stans in mice. Proc 1st Int Workshop on the Standardization and Utilization of Herbal Medicines: Challenges of the 21st Century, University of Ibadan, pp 178–184.Google Scholar
  12. 12.
    Park BH, Rho HW, Park JW, Cho CG, et al. (1995) New hypotheses for the mechanism of streptozotocin and alloxan inducing diabetes mellitus. Biochem Biophys Res Commun 210: 1–6.Google Scholar
  13. 13.
    West EE, Todd WR, Mason HS, Van Bruggeu JT (1966) Textbook of Biochemistry 4th edition. London: The Macmillan company limited.Google Scholar

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • O.O. Ogundipe
    • 1
  • J.O. Moody
    • 1
  • T.O. Akinyemi
    • 1
  • A. Raman
    • 2
  1. 1.Department of PharmacognosyFaculty of Pharmacy University of IbadanIbadanNigeria
  2. 2.Department of PharmacyKings CollegeLondonUK

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