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Diabetes Insipidus: Historical Aspects

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Abstract

The contributions to our present knowledge and understanding of diabetes insipidus are briefly surveyed. Though a disease presenting with polyuria and thirst had been recognized since Antiquity, it was not until the 17. Century the distinction was made between diabetes insipidus and diabetes mellitus. At the beginning of the 20. Century almost nothing was known about the function of the pituitary. It was generally believed that diabetes insipidus was a renal disease. Two clinical observations in 1912 suggested an association between the hypophysis and diabetes insipidus. This view was supported by the recognition in 1913 that extract of the posterior lobe of the pituitary was effective in diabetes insipidus. Despite much evidence to the contrary, it was assumed that the antidiuretic hormone was produced in the intermediate lobe of the pituitary. Around 1950 it was finally established that ‘the posterior lobe hormones’ are in fact secreted in the hypothalamus. At the same time the antidiuretic hormone was isolated and synthesized. More recently, progress within genetics has made it possible to characterize in details other rare types of diabetes insipidus.

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References

  1. Garrod AF. On glycosuria. Transact Med Soc Lond1912;31:131–199.

    Google Scholar 

  2. Frank JP. Behandlung der Krankheiten des Menschen. Berlin: Fincke. 1835;2:20–36.

    Google Scholar 

  3. Cullen W. First lines of the practice of physics. Edinburgh. 1791;4:82–93.

    Google Scholar 

  4. Medical facts and observations. London. 1792;2:73–101.

  5. Willis R. Urinary Diseases and Their Treatment. London: Sherwood, Gilbert & Piper 1838:1.27

    Google Scholar 

  6. Prout W. On the Nature and Treatment of Stomach and Renal diseases. Philadelphia: Lea & Blanchard 1843:43.

    Google Scholar 

  7. Bernard C. Leçons de physiologie experimentale appliqée a la medecin. Paris. 1855;288–318.

  8. Hagenbach K. Ein Fall von Diabetes Insipidus. Jahrb Kinderheilk1884;19:214–216.

    Google Scholar 

  9. Oliver G, Schäfer EA. On the physiological actions of pi-tuitary body and certain other glandular organs. J Physiol1895;18:277–279.

    PubMed  CAS  Google Scholar 

  10. Howell WH. The physiological effects of extracts of the hy-pophysis cerebri and infundibular body. J Exp Med1898;3:245–258.

    Article  CAS  PubMed  Google Scholar 

  11. Schäfer EA, Vincent J. The physiological effects of the pituitary body. J Physiol. 1899;25:87–97.

    PubMed  Google Scholar 

  12. Dale HH. On some physiological effects of ergot. J Physiol1906;34:163–206.

    CAS  PubMed  Google Scholar 

  13. Camus J, Roussy G. Experimental researches on the pituitary. Endocrinology1920;4:505–522.

    Article  Google Scholar 

  14. Aschner B. Über das "Stoffwechsel und Eingeweidecentrum im Zwischenhirn", seine Beziehung zum inneren Sekretion (Hypophyse, Zirbeldrüse) und zum Diabetes Insipidus. Berlin klin Wochenschr1916;532:772–775.

    Google Scholar 

  15. Mosler F. Neubildung im IV. Ventrikel mit nachfolgendem Diabetes Insipidus. Arch path Anat Physiol1868;43:225–229.

    Google Scholar 

  16. Fink EB. Diabetes insipidus. Arch Pathol1928;6:102–120.

    CAS  Google Scholar 

  17. Frank E. Über Beziehungen der Hypophyse zum Diabetes In-sipidus. Berlin klin Wochenschr. 1912;49:393–397.

    Google Scholar 

  18. Simmond M. Hypophysis und Diabetes Insipidus. Munch med Wochenschr. 1913;60:127–128.

    Google Scholar 

  19. Murray GR. Note on the treatment of myxoedema by hypoder-mic injections of an extract of the thyroid gland of a sheep. Br Med J1891;2:796–797.

    PubMed  Google Scholar 

  20. van der Velden R. Die Nierenwirkung von Hypophysenextrak-ten beim Menschen. Berlin klin Wochenschr1913;50:2083–2086.

    Google Scholar 

  21. Farini F. Diabete insipido ed opoterapia ipofisaria. Gazz Os-pedal Clin1913;34:1135–1139.

    Google Scholar 

  22. Farini A, Ceccaroni B. Influenza degli estratti ipofisari sull’eliminazione dell’acido ippurico. Gazz Ospedal Clin1913;34:879–882

    CAS  Google Scholar 

  23. Herring PT. A contribution to the comparative physiology of the pituitary body. Q JExp Physiol1908;1:262–280.

    Google Scholar 

  24. Bailey P. Die Funktion der Hypophysis cerebri. Ergeb Physiol1922;20:162–206.

    Google Scholar 

  25. Futcher TB. Diabetes insipidus and lesions of the mid-brain. Report of a case due to a metastatic tumor of the hypothala-mus. Am J Med Sci 1929;178:837–852.

    Google Scholar 

  26. Cushing H. Hyperactivation of the neurohypophysis as the pathological basis of ecclampsia and other hypertensive states. Am J Path 1934;10:145–175.

    CAS  PubMed  Google Scholar 

  27. Starling EH, Verney EB. The secretion of urine as studied on the isolated kidney. Proc R Soc Lond1925;97:421-363.

    Google Scholar 

  28. Verney EB. The secretion of pituitrin in mammals as shown by perfusion of the isolated kidney of the dog. Proc R Soc Lond1926;99:487–517.

    CAS  Google Scholar 

  29. Verney EB. The antidiuretic hormone and the factors which determine its release. Proc R Soc Lond1948;135:25–105.

    Article  Google Scholar 

  30. Trendelenburg P. Anteil der Hypophyse und des Hypothala-mus am experimentellen Diabetes Insipidus. Klin Wochenschr1928;7:1679–1680.

    Article  CAS  Google Scholar 

  31. Lower R. De catarrhis (1672). Reproduced in Facsimile. Lon-don: Dawsons. 1963:5–6.

    Google Scholar 

  32. Scharrer E, Scharrer B. Hormones produced by neurosecre-tory cells. Rec Prog Horm Res1954;10:183–232.

    CAS  Google Scholar 

  33. Bargmann W. Über die neurosekretorische Verknüppfung von Hypothalamus und Neurohypophyse. Z Zellforsch mikrosk Anat1949;34:610–634.

    PubMed  CAS  Google Scholar 

  34. Abel JJ. Physiological, chemical and clinical studies on pitu-itary principles. Bull Johns Hopkins Hosp1924;35:305–328

    CAS  Google Scholar 

  35. Kamm O, Aldrich TB, Grote IW, Rowe LW, Bugbee EP. The active principles of the posterior lobe of the pituitary gland. J Am Chem Soc1928;50:573–601.

    Article  CAS  Google Scholar 

  36. du Vigneaud V. Hormones of the posterior pituitary gland: oxy-tocin and vasopressin. Harvey Lect1956;50:1–26.

    Google Scholar 

  37. Acher R, Chauvet J. La structure de la vasopressine de boeuf. Biochim Biophys Acta1953;12:487–488.

    Article  PubMed  CAS  Google Scholar 

  38. Acher R, Chauvet J. La structure de la vasopressine de boeuf. Biochim Biophys Acta1954;14:421–429.

    Article  PubMed  CAS  Google Scholar 

  39. Blumgart HL. The antidiuretic effect of pituitary extract ap-plied intranasally in a case of diabetes insipidus. Arch Intern Med1922;29:508–514.

    CAS  Google Scholar 

  40. de Lange C. Über erblichen Diabetes Insipidus. Jahrb Kinder-heilk1935;145:1–14.

    Google Scholar 

  41. Forssman H. On hereditary diabetes insipidus. Acta med Scand: 1945;(Suppl 159):1–195.

    Google Scholar 

  42. Waring AJ, Kajdi L, Tappan V. A congenital defect of water metabolism. Am J Dis Child1945;69:323–324.

    Google Scholar 

  43. Williams RH, Henry C. Nephrogenic diabetes insipidus trans-mitted by females and appearing during infancy in males. An-nal Intern Med1947;27:84–95.

    CAS  Google Scholar 

  44. Nguyen MK, Nielsen S, Kurtz I. Molecular pathogenesis of nephrogenic diabetes insipidus. Clin Exp Nephrol2003;7:9–17

    Article  PubMed  CAS  Google Scholar 

  45. Braverman LE, Mancini JP, McGoldrick DM. Heredi-tary diabetes insipidus. Ann Intern Med1965;63:503–508.

    PubMed  CAS  Google Scholar 

  46. Christensen JH, Siggaard C, Rittig S. Autosomal domi-nant familial neurohypophyseal diabetes insipidus. APMIS2003;Suppl 109:92–95.

    Google Scholar 

  47. Durr JA. Diabetes insipidus in pregnancy. Am J Kidn Dis1987;9:276–283.

    CAS  Google Scholar 

  48. Durr JA, Haggard JG, Hunt JM, Schrier RW. Diabetes in-sipidus in pregnancy associated with abnormally high circu-lating vasopressinase activity. New Engl J Med1987;316:1070–1074.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Medicine, Division of Endocrinology, Holstebro Hospital, 7500, Holstebro, Denmark

    Jörgen Lindholm

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  1. Jörgen Lindholm
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Lindholm, J. Diabetes Insipidus: Historical Aspects. Pituitary 7, 33–38 (2004). https://doi.org/10.1023/B:PITU.0000044633.52516.e1

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  • DOI: https://doi.org/10.1023/B:PITU.0000044633.52516.e1

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