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Response of Neoplastic Meningitis from Solid Tumors to Oral Capecitabine

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An Erratum to this article was published on 01 July 2004

Abstract

Neoplastic meningitis (NM) is a major challenge for the neuro-oncologist as it constitutes a relatively common clinical problem in systemic and central nervous system cancers, and is very difficult to treat. NM portends a significant worsening in prognosis. Chemotherapeutic treatment options are limited, and not particularly effective. We report two cases of NM from breast carcinoma and a third with esophageal carcinoma, which responded to treatment with capecitabine, an oral prodrug for 5-flurouracil. We believe capecitabine warrants further investigation in patients with NM. In some patients, its use may result in clinical and radiographic tumor responses, improved quality of life, and possibly increased survival.

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Authors and Affiliations

  1. Neuro-Oncology Department, University of Texas – M.D. Anderson Cancer Center, TX, USA

    Pierre Giglio, Ivo W. Tremont-Lukats & Morris D. Groves

Authors
  1. Pierre Giglio
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  2. Ivo W. Tremont-Lukats
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  3. Morris D. Groves
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Additional information

An erratum to this article is available at http://dx.doi.org/10.1023/B:NEON.0000033498.26548.ad.

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Giglio, P., Tremont-Lukats, I.W. & Groves, M.D. Response of Neoplastic Meningitis from Solid Tumors to Oral Capecitabine. J Neurooncol 65, 167–172 (2003). https://doi.org/10.1023/B:NEON.0000003752.89814.ca

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  • DOI: https://doi.org/10.1023/B:NEON.0000003752.89814.ca

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