Abstract
The characteristics of the actions of the non-competitive blocker of NMDA receptors dizocilpine on the expression of the early c-fos gene in the paraventricular nuclei of the hypothalamus were studied in rats with different predicted susceptibilities to emotional stress in conditions of treatment with delta sleep-inducing peptide. The results showed that prior treatment with dizocilpine blocked reductions in c-fos expression induced by delta sleep peptide.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
E. V. Koplik, Yu. A. Gryzunov, L. V. Kapaeva, G. E. Dobretsov, and K. V. Sudakov, “Levels of non-esterified fatty acids in the albumin fraction of the blood in rats with different levels of movement activity in the open field,” Dokl. Ros. Akad. Nauk., 378,No. 1, 1–3 (2001).
L. B. Piotrovskii, “The search for substances with selective actions on mediator transmission by excitatory amino acids,” Vestn. Ros. Akad. Med. Nauk., 7, 57–62 (1992).
K. V. Sudakov, “The antistress effects of delta sleep-inducing peptide,” Fiziol. Zh. SSSR, 77,No. 3, 3–15 (1991).
P. E. Umryukhin, “Early genes in the cerebral mechanisms of emotional stress,” Usp. Fiziol. Nauk., 31,No. 1, 54–70 (2002).
E. K. Michaelis, “Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging,” Progr. Neurobiol., 54,No. 4, 369–415 (1998).
G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego (1998).
M. Scheng and M. E. Greenberg, “The regulation of c-fos and other immediate early genes in the nervous system,” Neuron, 4, 477–485 (1990).
K. V. Sudakov, P. E. Umriukhin, E. V. Koplik, and K. V. Anokhin, “Delta sleep-inducing peptide (DSIP) and ACTH(4-10) analogue influences Fos-induction in the limbic structures of the rat brain under emotional stress,” Stress, 4,No. 2, 143–153 (2001).
Y. Yonedo, N. Kuramoto, T. Kitayama, and E. Hinoi, “Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain,” Progr. Neurobiol., 63,No. 6, 697–719 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Umryukhin, P.E., Anokhin, K.V. & Raevskii, K.S. Dizocilpine Blocks the Effects of Delta Sleep-Inducing Peptide-Induced Suppression of c-fos Gene Expression in the Paraventricular Nucleus of the Hypothalamus in Rats. Neurosci Behav Physiol 34, 501–503 (2004). https://doi.org/10.1023/B:NEAB.0000022637.57852.e0
Issue Date:
DOI: https://doi.org/10.1023/B:NEAB.0000022637.57852.e0