Abstract
Experiments on white rats were performed to study the effects of bilateral lesioning of the striatum on activation of the hypothalamo–hypophyseal–adrenal system (HHAS) after unilateral adrenalectomy. These studies showed that increases in the weight of the surviving adrenal gland were smaller in striatectomized rats than in controls. There was a significant decrease in corticosteroid production by the intact gland. These changes were most marked after destruction of the dorsal parts of the nucleus. These data provide evidence for involvement of the striatum in controlling HHAS activity via a feedback mechanism.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
É. V. Beier, E. V. Shchetinin, and É. B. Arushanyan, “Effects of lesioning the striatum on the dynamics, cardiointervalogram, and its circadian variation in rats,” Fiziol. Zh. im. I. M. Sechenova, 81,No. 10, 26–31 (1995).
N. L. Voilokova, N. F. Suvorov, V. V. Rakitskaya, I. A. Garina, and V. G. Shalyapina, “Conditioned reflex behavior in dogs during intracaudate administration of corticoliberin,” Zh. Vyssh. Nerv. Deyat., 44,No. 3, 585–590 (1994).
E. N. Gorban', “Age-related features of the effects of α-and β-adrenomimetics on the glucocorticoid function of the adrenal cortex,” Byull. Éksperim. Biol. Med., 106,No. 4, 343–345 (1991).
I. I. Dedov, G. A. Mel'nichenko, and V. V. Fadeev, Endocrinology [in Russian], Meditsina, Moscow (2000).
D. A. Zhukov, “Comparison of the responses of the hypophysisadrenal system in rats to inhibitory and excitatory stimuli,” Fiziol. Zh. SSSR, 88,No. 2, 95–99 (1991).
S. Katsuki, Central Regulation of the Functions of Endocrine Glands [in Russian], Nauka, Moscow (1971).
Ya. D. Kirshenglat, L. K. Kitsis, L. N. Kreshchuk, and N. S. Sobolev, “Involvement of the vagus nerves in controlling the functions of the adrenal cortex,” Probl. Éndokrinol., 17,No. 2, 72–75 (1971).
M. T. MacDermot, S. Kliment, and D. V. D. E.-B. Torrens, Secrets of Endocrinology [Russian translation], Binom Press, Moscow (1998).
V. A. Otellin and E. B. Arushanyan, The Nigrostriatal System [in Russian], Meditsina, Moscow (1989).
V. V. Rakitskaya, N. L. Voilokova, I. A. Garina, N. F. Suvorov, and V. G. Shalyapina, “Neuroendocrine functions and behavior in dogs after administration of corticoliberin into the caudate nucleus,” Ros. Fiziol. Zh. im. I. M. Sechenova, 78,No. 1, 29–34 (1992).
V. V. Rakitskaya, V. G. Shalyapina, N. L. Voilokova, N. F. Suvorov, and E. V. Turkina, “Activation of the sympathetic-adrenal system by administration of corticoliberin into the caudate nucleus in dogs,” Probl. Éndokrinol., 39,No. 6, 50–51 (1993).
A. G. Reznikov, Methods for Hormone Estimation. A Handbook [in Russian], Naukova Dumka, Kiev (1980).
A. A. Serebryakova, “Age-related features of the responses of the hypothalamo—hypophyseal—adrenocortical system in the rat to unilateral adrenalectomy,” in: Neuroendocrine Mechanisms of Adaptation [in Russian], SGPI Press, Stavropol', Issue 1, pp. 35–42 (1974).
É. Kh. Sirel', A. A. Viru, and T. P. Sééne, “The effects of adrenal denervation on adrenal hypertrophy during training,” in: Neuroendocrine Mechanisms of Adaptation [in Russian], SGPI Press, Stavropol', pp. 28–34 (1980).
N. F. Suvorov, N. L. Voilokova, A. I. Gorbachevskaya, and A. V. Mikhailov, “Striato-nigrothalamic mechanisms of the organization of behavior,” Ros. Fiziol. Zh. im. I. M. Sechenova, 81,No. 4, 1–11 (1995).
J. Tepperman and H. Tepperman, Basic Physiology of Metabolism and the Endocrine System [Russian translation], Mir, Moscow (1989).
A. V. Tonkikh, The Hypothalamo-Hypophyseal Region and Control of Physiological Functions in the Body [in Russian], Nauka, Leningrad (1968).
E. V. Turkina, E. A. Rybnikova, and V. G. Shalyapina, “Involvement of the neostriatum in mediating the effects of corticoliberin on the hormonal function of the adrenal glands,” Ros. Fiziol. Zh. im. I. M. Sechenova, 82,No. 5–6, 109–113 (1996).
M. Ya. Usvatova and Yu. Ya. Pankov, “A fluorimetric method for estimating 11-hydroxycorticosteroids in peripheral blood plasma,” in: Studies of New Instruments and Methods, MOLMI, I,No. 3, pp. 137–145 (1965).
E. V. Chernigovskaya, O. A. Danilova, and M. A. Belen'kii, “Characteristics of the neurosecretory centers of the rat hypothalamus, associated with controlling the functions of the adrenal cortex,” Probl. Éndokrinol., 34,No. 1, 60–64 (1988).
V. G. Shalyapina, “Functional oscillations in the neuroendocrine regulation of stress,” Ros. Fiziol. Zh. im. I. M. Sechenova, 82,No. 4, 9–14 (1996).
V. G. Shalyapina, M. P. Markova, I. A. Garina, and V. V. Rakitskaya, “The hypophyseal-adrenocortical system in rats with spontaneous and steroid hypertension,” in: Ontogenetic and Genetic-Evolutionary Aspects of the Neuroendocrine Regulation of Stress [in Russian], Nauka, Novosibirsk (1990), pp. 125–136.
V. G. Shalyapina, V. V. Rakitskaya, I. A. Garina, N. L. Voilokova, and N. F. Suvorov, “Administration of corticoliberin into the caudate nucleus activates the sympatheticoadrenomedullary and hypophyseal—adrenocortical systems by different mechanisms,” Ros. Fiziol. Zh. im. I. M. Sechenova, 79,No. 1, 92–98 (1993).
B. G. Charlton, “Noradrenergic innervation to the adrenal cortex is responsible for control of basal glucocorticoid secretion. A model,” Med. Hypotheses, 44,No. 3, 214–216 (1995).
A. V. Edwards and C. T. Jones, “Cholinergic adrenal responses to splanchnic nerve stimulation in conscious calves,” J. Physiol. (London), 459, 433 (1993).
G. I. Etcheverry, “Ultrastructure of neurons in the circulate nucleus of the rat,” Anat. Rec., 160, 239–254 (1968).
F. I. Gonzales and J. M. L. Cillero, “Influencia del sistema nervioso simpatico en la funcion corticosuprarenal de la rata,” Endocrinologia, 33,No. 6, 183–186 (1986).
F. C. Konig and R. A. Klippel, The Rat Brain, Williams and Wilkins, Baltimore (1963).
X. Luo, A. Kiss, C. Rabadan-Diehl, and G. Aguilera, “Regulation of hypothalamic and pituitary corticotropin-releasing hormone receptor messenger ribonucleic acid by adrenalectomy and glucocorticoids,” Endocrinology, 136,No. 9, 3877–3883 (1995).
A. Polenov, I. Krasnovskaya, and V. Kuzic, “Nonapeptide neurohormones of hypothalamo-hypophyseal neurosecretory system (HHNS) may influence peripheral endocrine glands via phylogenetically old paraadrenohypophyseal route,” Gen. Comp. Endocrinol., 66,No. 1, 7–8 (1987).
P. Seeman, “Brain dopamine receptors,” Pharmacol. Rev., 32, 229–331 (1980).
E. B. de Souza and G. R. van Loon, “Differential plasma endorphin β-lipotropin and adrenocorticotropin responses to stress in rats,” J. Endocrinol., 116,No. 4, 1577–1586 (1985).
E. B. de Souza, “Corticotropin-releasing factor receptors in the rat brain and pituitary: their role in the stress responses,” in: Neuropeptides and Stress, J. Tache, et al. (eds.), Springer (1989), p. 49.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Baturin, V.A., Samokhvalova, T.N. The Effects of Lesions to the Striatum on the Function of the Hypothalamo–Hypophyseal–Adrenal System in Adrenalectomized Rats. Neurosci Behav Physiol 34, 439–444 (2004). https://doi.org/10.1023/B:NEAB.0000022627.49404.93
Issue Date:
DOI: https://doi.org/10.1023/B:NEAB.0000022627.49404.93